Germline-targeting immunogens guide bnab development

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Structure-guided protein design enables germline-targeting immunization strategies to generate broadly neutralizing antibodies against MPER, a region of the HIV envelope glycoprotein that is


functionally important and highly conserved, but a challenging target for antibody responses. Access through your institution Buy or subscribe This is a preview of subscription content,


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institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Burton, D. R. & Hangartner, L. _Annu. Rev. Immunol._ 34, 635–659 (2016). Article  CAS  PubMed  PubMed


Central  Google Scholar  * Sneller, M. C. et al. _Nature_ 606, 375–381 (2022). Article  CAS  PubMed  PubMed Central  Google Scholar  * Schiffner, T. et al. _Nat. Immunol._


https://doi.org/10.1038/s41590-024-01833-w (2024). Article  PubMed  Google Scholar  * Ray, R. et al. _Nat. Immunol._ https://doi.org/10.1038/s41590-024-01844-7 (2024). Article  PubMed 


Google Scholar  * Julien, J.-P. et al. _Science_ 342, 1477–1483 (2013). Article  CAS  PubMed  Google Scholar  * Haynes, B. F. et al. _Nat. Rev. Immunol._ 23, 142–158 (2023). Article  CAS 


PubMed  Google Scholar  * Huang, J. et al. _Nature_ 491, 406–412 (2012). Article  CAS  PubMed  PubMed Central  Google Scholar  * Jardine, J. G. et al. _Science_ 351, 1458–1463 (2016).


Article  CAS  PubMed  PubMed Central  Google Scholar  * Leggat, D. J. et al. _Science_ 378, eadd6502 (2022). Article  CAS  PubMed  PubMed Central  Google Scholar  Download references AUTHOR


INFORMATION AUTHORS AND AFFILIATIONS * Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA Tobias V. Lanz * Division of Immunology and Rheumatology,


Department of Medicine, Stanford University, Stanford, CA, USA Tobias V. Lanz Authors * Tobias V. Lanz View author publications You can also search for this author inPubMed Google Scholar


CORRESPONDING AUTHOR Correspondence to Tobias V. Lanz. ETHICS DECLARATIONS COMPETING INTERESTS The author declares no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions


ABOUT THIS ARTICLE CITE THIS ARTICLE Lanz, T.V. Germline-targeting immunogens guide bnAb development. _Nat Immunol_ 25, 944–946 (2024). https://doi.org/10.1038/s41590-024-01852-7 Download


citation * Published: 30 May 2024 * Issue Date: June 2024 * DOI: https://doi.org/10.1038/s41590-024-01852-7 SHARE THIS ARTICLE Anyone you share the following link with will be able to read


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