Targeting proteins to lysosomes with a chemical inducer of arginine methylation

Arginine methylation acts as a signal for intracellular proteins to be degraded in lysosomes. We developed methylarginine targeting chimera (MrTAC), a chemical tool that induces proximity

with protein arginine _N_-methyltransferase 1 (PRMT1) to trigger arginine methylation and thus targeted protein degradation in lysosomes. Access through your institution Buy or subscribe

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institutional affiliations. THIS IS A SUMMARY OF: Seabrook, L. J. et al. Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins. _Nat. Chem. Biol_.

https://doi.org/10.1038/s41589-024-01741-y (2024). RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Targeting proteins to lysosomes with a chemical

inducer of arginine methylation. _Nat Chem Biol_ 20, 1564–1565 (2024). https://doi.org/10.1038/s41589-024-01744-9 Download citation * Published: 22 October 2024 * Issue Date: December 2024 *

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