Micropolarized to the core | Nature Chemical Biology

Macromolecules can undergo liquid–liquid phase separation to form condensates that have critical roles in biological functions and dysfunctions. A new study demonstrates that differences in

micropolarity between components is a prime determinant of the multiphasic architecture of biomolecular condensates. Access through your institution Buy or subscribe This is a preview of

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* Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Alberti, S. & Hyman, A. A. _Nat. Rev. Mol. Cell Biol._ 22, 196–213 (2021).

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al. _Nat. Commun._ 12, 5579 (2021). Article  CAS  PubMed  PubMed Central  Google Scholar  Download references ACKNOWLEDGEMENTS Grant support was provided by NINDS, NIH to A.C.M.F. (R01

NS105874 and R21 NS107792), and by NIGMS, NIH (R01 GM122763) and the Welch Foundation (Q-2097-20220331) to J.C.F. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Biochemistry and

Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA My Diem Quan, Josephine C. Ferreon & Allan Chris M. Ferreon Authors * My Diem Quan View author publications You can

also search for this author inPubMed Google Scholar * Josephine C. Ferreon View author publications You can also search for this author inPubMed Google Scholar * Allan Chris M. Ferreon View

author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Allan Chris M. Ferreon. ETHICS DECLARATIONS COMPETING INTERESTS The

authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Quan, M.D., Ferreon, J.C. & Ferreon, A.C.M. Micropolarized to

the core. _Nat Chem Biol_ 20, 399–400 (2024). https://doi.org/10.1038/s41589-024-01542-3 Download citation * Published: 07 February 2024 * Issue Date: April 2024 * DOI:

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