Capturing and modeling cellular niches from dissociated single-cell and spatial data

Cells interact with their local environment to enact global tissue function. By harnessing gene–gene covariation in cellular neighborhoods from spatial transcriptomics data, the covariance

environment (COVET) niche representation and the environmental variational inference (ENVI) data integration method model phenotype–microenvironment interplay and reconstruct the spatial

context of dissociated single-cell RNA sequencing datasets. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS

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cellular niches for spatial inference. _Nat. Biotechnol_. https://doi.org/10.1038/s41587-024-02193-4 (2024) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE Capturing and modeling cellular niches from dissociated single-cell and spatial data. _Nat Biotechnol_ 43, 179–180 (2025). https://doi.org/10.1038/s41587-024-02207-1 Download

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