Mapping the global landscape for induced pluripotent stem cells from patents and clinical trials

Although the clinical application of induced pluripotent stem cells is still in its infancy, the development of iPSC technologies reflected by an increasing number of patents provides hope

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Contact customer support REFERENCES * Takahashi, K. & Yamanaka, S. _Cell_ 126, 663–676 (2006). Article  CAS  PubMed  Google Scholar  * Thomson, J. A. et al. _Science_ 282, 1145–1147

(1998). Article  CAS  PubMed  Google Scholar  * Yu, J. et al. _Science_ 318, 1917–1920 (2007). Article  CAS  PubMed  Google Scholar  * Yamanaka, S. _Cell Stem Cell_ 27, 523–531 (2020).

Article  CAS  PubMed  Google Scholar  * Kamao, H. et al. _Stem Cell Reports_ 2, 205–218 (2014). Article  CAS  PubMed  PubMed Central  Google Scholar  * Goodridge, J. P. et al. _Blood_ 134,

301 (2019). Article  Google Scholar  * Kleiman, R. J. & Engle, S. J. _Cell Stem Cell_ 28, 1507–1515 (2021). Article  CAS  PubMed  Google Scholar  * Patel, M. & Yang, S. _Stem Cell

Rev. Rep._ 6, 367–380 (2010). Article  CAS  PubMed  Google Scholar  * Takahashi, K. & Yamanaka, S. _Nat. Rev. Mol. Cell Biol._ 17, 183–193 (2016). Article  CAS  PubMed  Google Scholar  *

Warren, L. et al. _Cell Stem Cell_ 7, 618–630 (2010). Article  CAS  PubMed  PubMed Central  Google Scholar  * Miyazaki, T. et al. _Nat. Commun._ 3, 1236 (2012). Article  PubMed  Google

Scholar  * Tiscornia, G., Vivas, E. L. & Izpisúa Belmonte, J. C. _Nat. Med._ 17, 1570–1576 (2011). Article  CAS  PubMed  Google Scholar  * McCauley, H. A. & Wells, J. M.

_Development_ 144, 958–962 (2017). Article  CAS  PubMed  PubMed Central  Google Scholar  * Lee, G. et al. _Nature_ 461, 402–406 (2009). Article  CAS  PubMed  PubMed Central  Google Scholar 

* Song, B. et al. _J. Clin. Invest._ 130, 904–920 (2020). Article  CAS  PubMed  PubMed Central  Google Scholar  * Li, M. et al. _Nat. Commun._ 13, 6354 (2022). Article  CAS  PubMed  PubMed

Central  Google Scholar  * Mandai, M. et al. _N. Engl. J. Med._ 376, 1038–1046 (2017). Article  CAS  PubMed  Google Scholar  * da Cruz, L. et al. _Nat. Biotechnol._ 36, 328–337 (2018).

Article  PubMed  Google Scholar  * Lund, R. J., Närvä, E. & Lahesmaa, R. _Nat. Rev. Genet._ 13, 732–744 (2012). Article  CAS  PubMed  Google Scholar  * Bravery, C. A. _Stem Cells Dev._

24, 1–10 (2015). Article  PubMed  Google Scholar  * Ben Jehuda, R., Shemer, Y. & Binah, O. _Stem Cell Rev. Rep._ 14, 323–336 (2018). Article  PubMed  Google Scholar  * Hockemeyer, D.

& Jaenisch, R. _Cell Stem Cell_ 18, 573–586 (2016). Article  CAS  PubMed  PubMed Central  Google Scholar  * Cong, L. et al. _Science_ 339, 819–823 (2013). Article  CAS  PubMed  PubMed

Central  Google Scholar  * Huang, D. et al. _Cell Discov._ 8, 121 (2022). Article  CAS  PubMed  PubMed Central  Google Scholar  * Morvan, M. G. & Lanier, L. L. _Nat. Rev. Cancer_ 16,

7–19 (2016). Article  CAS  PubMed  Google Scholar  * Lupo, K. B. & Matosevic, S. _Cancers (Basel)_ 11, 769 (2019). Article  CAS  PubMed  Google Scholar  * Chen, S., Sun, H., Miao, K.

& Deng, C. X. _Int. J. Biol. Sci._ 12, 1427–1436 (2016). Article  CAS  PubMed  PubMed Central  Google Scholar  * Li, Y., Hermanson, D. L., Moriarity, B. S. & Kaufman, D. S. _Cell

Stem Cell_ 23, 181–192.e5 (2018). Article  CAS  PubMed  PubMed Central  Google Scholar  * Martins-Taylor, K. et al. _Nat. Biotechnol._ 29, 488–491 (2011). Article  CAS  PubMed  Google

Scholar  * Zhao, T., Zhang, Z. N., Rong, Z. & Xu, Y. _Nature_ 474, 212–215 (2011). Article  CAS  PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS This research was supported

with the Ministry of Science and Technology National Key R&D grant (2022YFA1105000), National Science Foundation China general grant (32270842), Macau Science and Technology Development

Fund (FDCT) grants (0002-2021-AKP and 0071-2022-A2), University of Macau (UM) grants (CPG2024-00037-FHS, MYRG2020-00140-FHS and MYRG2022-00044-FHS) to R.X., as well as FDCT grants

(005/2023/SKL and SKL-QRCM(UM)-2023-2025), UM grants (MYRG2022-00103-ICMS and MYRG-CRG2023-00007-ICMS-IAS) and Zhuhai UM Science & Technology Research Institute grant (CP-033-2021) to

Y.J.H. AUTHOR INFORMATION Author notes * These authors contributed equally: Liyang Lyu, Ye Feng, Borong Huang. AUTHORS AND AFFILIATIONS * State Key Laboratory of Quality Research in Chinese

Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China Liyang Lyu, Ye Feng & Yuanjia Hu * Center of Reproduction, Development & Aging, and Institute

of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China Borong Huang & Ren-He Xu * Ministry of Education Frontiers Science Center for Precision

Oncology, University of Macau, Macao SAR, China Borong Huang & Ren-He Xu * DPM, Faculty of Health Sciences, University of Macau, Macao SAR, China Yuanjia Hu * Centre for Pharmaceutical

Regulatory Sciences, University of Macau, Macao SAR, China Yuanjia Hu Authors * Liyang Lyu View author publications You can also search for this author inPubMed Google Scholar * Ye Feng View

author publications You can also search for this author inPubMed Google Scholar * Borong Huang View author publications You can also search for this author inPubMed Google Scholar * Ren-He

Xu View author publications You can also search for this author inPubMed Google Scholar * Yuanjia Hu View author publications You can also search for this author inPubMed Google Scholar

CORRESPONDING AUTHORS Correspondence to Ren-He Xu or Yuanjia Hu. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. SUPPLEMENTARY INFORMATION SUPPLEMENTARY

INFORMATION Supplementary Methods, Supplementary Fig 1 SUPPLEMENTARY DATA Listing of 11,252 patents RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Lyu,

L., Feng, Y., Huang, B. _et al._ Mapping the global landscape for induced pluripotent stem cells from patents and clinical trials. _Nat Biotechnol_ 42, 563–569 (2024).

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