Draining OA from the synovium | Nature Reviews Rheumatology


Play all audios:

Access through your institution Buy or subscribe Dysfunction of the synovial lymphatic system (SLS) has been implicated in the pathogenesis of inflammatory arthritis, including rheumatoid


arthritis and post-traumatic osteoarthritis (OA), but its role in age-related OA has largely remained unexplored. Evidence now suggests that impaired SLS function contributes to the


progression of age-related OA and that it could be therapeutically targeted by administration of vascular endothelial growth factor C (VEGF-C), the main growth factor for lymphatic


endothelial cells. Using a new in vivo imaging approach to measure lymphatic influx and clearance of intra-articularly administered dextran macromolecules, Lin et al. demonstrated that SLS


function is impaired in the knees of aged mice (19–24 months old) as compared with those of young mice (3 months old), with aged knees having decreased joint clearance, synovial influx and


draining lymph node capacity. The expression of _Vegfc_ and other genes related to signalling via the VEGF-C receptor VEGFR was also decreased in synovial tissue from aged mice, as


demonstrated by RNA-sequencing analysis. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other


Nature Portfolio journals Get Nature+, our best-value online-access subscription $29.99 / 30 days cancel any time Learn more Subscribe to this journal Receive 12 print issues and online


access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which


are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Lin, X.


et al. Targeting synovial lymphatic function as a novel therapeutic intervention for age-related osteoarthritis in mice. _Arthritis Rheumatol._ https://doi.org/10.1002/art.42441 (2023)


Article  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Rheumatology http://www.nature.com/nrrheum/ Sarah Onuora Authors * Sarah


Onuora View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Sarah Onuora. RIGHTS AND PERMISSIONS Reprints and


permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Onuora, S. Draining OA from the synovium. _Nat Rev Rheumatol_ 19, 130 (2023). https://doi.org/10.1038/s41584-023-00919-3 Download citation *


Published: 31 January 2023 * Issue Date: March 2023 * DOI: https://doi.org/10.1038/s41584-023-00919-3 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this


content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative