Autoantibodies disrupt muscle repair and promote iim progression

Access through your institution Buy or subscribe New research suggests that tripartite motif (TRIM) family proteins act as autoantigens in idiopathic inflammatory myopathy (IIM) and

contribute to disease progression via a positive feedback loop. The findings of the study suggest that antibodies against these proteins compromise muscle membrane repair, and decreased

sarcolemmal integrity leads to aberrant autoantigen presentation that promotes autoimmunity. The researchers demonstrated that adoptive transfer of lymph node cells from

_Foxp3__–/Y__Syt7_–/– mice into recipient _Rag1_–/– mice resulted in severe inflammation in proximal muscle whereas distal muscle was spared, recapitulating the pattern seen in patients with

IIM. Notably, distal skeletal muscle had impaired membrane integrity and reduced capacity for membrane repair following injury in the absence of inflammation. This is a preview of

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* Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * McElhanon, K. E. et al. Autoantibodies targeting TRIM72 compromise

membrane repair and contribute to inflammatory myopathy. _J. Clin. Invest._ 6, eaba4353 (2020) Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature

Reviews Rheumatology http://www.nature.com/nrrheum/ Sarah Onuora Authors * Sarah Onuora View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING

AUTHOR Correspondence to Sarah Onuora. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Onuora, S. Autoantibodies disrupt muscle repair and promote IIM

progression. _Nat Rev Rheumatol_ 16, 473 (2020). https://doi.org/10.1038/s41584-020-0488-z Download citation * Published: 31 July 2020 * Issue Date: September 2020 * DOI:

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