Soluble cd83: a proresolving mediator in inflammatory arthritis?

Access through your institution Buy or subscribe The soluble form of CD83 (sCD83) has immunomodulatory properties, including the ability to induce tolerogenic dendritic cell and regulatory T

(Treg) cell responses, but its involvement in inflammatory arthritis has, until now, been unclear. “We show for the first time that sCD83 has anti-inflammatory properties in arthritis and

induces resolution of inflammation,” explains Elisabeth Zinser, co-corresponding author of a new study. “Interestingly, sCD83 treatment not only reduced joint swellings, but also inhibited

expression of important pro-inflammatory cytokines,” reports co-corresponding author Alexander Steinkasserer. This is a preview of subscription content, access via your institution ACCESS

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FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Royzman, D. et al. Soluble CD83 triggers resolution of arthritis and sustained inflammation control in IDO dependent manner.

_Front. Immunol._ https://doi.org/10.3389/fimmu.2019.00633 (2019) Article  PubMed  PubMed Central  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature

Reviews Rheumatology http://www.nature.com/nrrheum/ Jessica McHugh Authors * Jessica McHugh View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING

AUTHOR Correspondence to Jessica McHugh. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE McHugh, J. Soluble CD83: a proresolving mediator in

inflammatory arthritis?. _Nat Rev Rheumatol_ 15, 319 (2019). https://doi.org/10.1038/s41584-019-0224-8 Download citation * Published: 26 April 2019 * Issue Date: June 2019 * DOI:

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