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Access through your institution Buy or subscribe The soluble form of CD83 (sCD83) has immunomodulatory properties, including the ability to induce tolerogenic dendritic cell and regulatory T
(Treg) cell responses, but its involvement in inflammatory arthritis has, until now, been unclear. “We show for the first time that sCD83 has anti-inflammatory properties in arthritis and
induces resolution of inflammation,” explains Elisabeth Zinser, co-corresponding author of a new study. “Interestingly, sCD83 treatment not only reduced joint swellings, but also inhibited
expression of important pro-inflammatory cytokines,” reports co-corresponding author Alexander Steinkasserer. This is a preview of subscription content, access via your institution ACCESS
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FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Royzman, D. et al. Soluble CD83 triggers resolution of arthritis and sustained inflammation control in IDO dependent manner.
_Front. Immunol._ https://doi.org/10.3389/fimmu.2019.00633 (2019) Article PubMed PubMed Central Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature
Reviews Rheumatology http://www.nature.com/nrrheum/ Jessica McHugh Authors * Jessica McHugh View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING
AUTHOR Correspondence to Jessica McHugh. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE McHugh, J. Soluble CD83: a proresolving mediator in
inflammatory arthritis?. _Nat Rev Rheumatol_ 15, 319 (2019). https://doi.org/10.1038/s41584-019-0224-8 Download citation * Published: 26 April 2019 * Issue Date: June 2019 * DOI:
https://doi.org/10.1038/s41584-019-0224-8 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
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