Α-crystallin b autoimmunity and multiple sclerosis


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Access through your institution Buy or subscribe Autoantibodies and T cells that target Epstein–Barr virus (EBV) nuclear antigen 1 (EBNA1) could contribute to the pathogenesis of multiple


sclerosis (MS) by cross-reacting with the heat shock protein α-crystallin B (CRYAB), a new study indicates. Researchers identified EBNA1–CRYAB cross-reactive antibodies in plasma samples


from individuals with MS. Mice that were immunized with recombinant CRYAB or an EBNA1 peptide generated T cells that recognized both proteins, and EBNA1–CRYAB cross-reactive T cells were


also found in people with MS. These observations might help to explain the strong epidemiological link between EBV infection and MS. This is a preview of subscription content, access via


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subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Thomas, O. G. et al. Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with


multiple sclerosis. _Sci. Adv._ 9, eadg3032 (2023) Article  CAS  PubMed  PubMed Central  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews


Neurology http://www.nature.com/nrneurol/ Heather Wood Authors * Heather Wood View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR


Correspondence to Heather Wood. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wood, H. α-Crystallin B autoimmunity and multiple sclerosis. _Nat Rev


Neurol_ 19, 387 (2023). https://doi.org/10.1038/s41582-023-00833-y Download citation * Published: 06 June 2023 * Issue Date: July 2023 * DOI: https://doi.org/10.1038/s41582-023-00833-y SHARE


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