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Deep skin injuries in adult humans lead to fibrotic scarring that compromises tissue function, whereas human fetal skin undergoes scarless healing. Understanding the mechanisms of skin
regeneration should lead to more effective treatments for skin wounds. Sinha et al. report a single-cell analysis of reindeer antler velvet, as a model of regenerative healing, showing that
fibroblast–immune cell interactions are key determinants of wound healing outcome.
Full-thickness excisional skin wounds were created in the back skin and antler velvet of adult reindeer. At 30 days post wounding (30 dpw), back skin wounds had generated hypertrophic scars
whereas antler skin wounds lacked scarring and had new hair follicles and restoration of the extracellular matrix architecture. When full-thickness velvet was ectopically transplanted to the
back skin of the same animal, it retained regenerative competence indicating that this is an intrinsic feature of velvet tissue.
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