Reindeer antlers model skin regeneration

Access through your institution Buy or subscribe Deep skin injuries in adult humans lead to fibrotic scarring that compromises tissue function, whereas human fetal skin undergoes scarless

healing. Understanding the mechanisms of skin regeneration should lead to more effective treatments for skin wounds. Sinha et al. report a single-cell analysis of reindeer antler velvet, as

a model of regenerative healing, showing that fibroblast–immune cell interactions are key determinants of wound healing outcome. Full-thickness excisional skin wounds were created in the

back skin and antler velvet of adult reindeer. At 30 days post wounding (30 dpw), back skin wounds had generated hypertrophic scars whereas antler skin wounds lacked scarring and had new

hair follicles and restoration of the extracellular matrix architecture. When full-thickness velvet was ectopically transplanted to the back skin of the same animal, it retained regenerative

competence indicating that this is an intrinsic feature of velvet tissue. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your

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REFERENCES ORIGINAL ARTICLE * Sinha, S. et al. Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer. _Cell_

https://doi.org/10.1016/j.cell.2022.11.004 (2022) Article  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Immunology

http://www.nature.com/nri/ Kirsty Minton Authors * Kirsty Minton View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to

Kirsty Minton. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Minton, K. Reindeer antlers model skin regeneration. _Nat Rev Immunol_ 23, 71 (2023).

https://doi.org/10.1038/s41577-022-00828-8 Download citation * Published: 13 December 2022 * Issue Date: February 2023 * DOI: https://doi.org/10.1038/s41577-022-00828-8 SHARE THIS ARTICLE

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