Adjuvant chemotherapy guided by circulating tumour dna in stage ii colon cancer


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Access through your institution Buy or subscribe Results have been reported for a randomized clinical trial assessing the use of adjuvant chemotherapy for colon cancer in patients with


circulating tumour DNA (ctDNA) post-surgery. Post-surgery ctDNA predicts low recurrence-free survival. Patients with stage II colon cancer were assigned to either management guided by


presence of ctDNA 4 or 7 weeks after surgery (_n = _302), initiating a chemotherapy regimen, or standard management (_n = _153). Two-year recurrence-free survival (the primary end point) for


ctDNA-guided management was noninferior to standard management (93.5% and 92.4%, respectively), and the ctDNA-guided approach reduced use of adjuvant chemotherapy. This is a preview of


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* Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Tie, J. et al. Circulating tumor DNA analysis guiding adjuvant


therapy in stage II colon cancer. _N. Engl. J. Med._ 386, 2261–2272 (2022) Article  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews


Gastroenterology & Hepatology http://www.nature.com/nrgastro/ Jordan Hindson Authors * Jordan Hindson View author publications You can also search for this author inPubMed Google Scholar


CORRESPONDING AUTHOR Correspondence to Jordan Hindson. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hindson, J. Adjuvant chemotherapy guided by


circulating tumour DNA in stage II colon cancer. _Nat Rev Gastroenterol Hepatol_ 19, 488 (2022). https://doi.org/10.1038/s41575-022-00656-0 Download citation * Published: 30 June 2022 *


Issue Date: August 2022 * DOI: https://doi.org/10.1038/s41575-022-00656-0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link


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