Microbial metabolite linked to t2dm


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Access through your institution Buy or subscribe In 2013, Fredrik Bäckhed and colleagues reported that the microbiota is altered in patients with type 2 diabetes mellitus (T2DM), but the


potential mechanisms and consequences of the changes have remained unclear. Now, the team have found that the concentrations of a metabolite derived from histidine, imidazole propionate, are


higher in the portal vein of patients with T2DM who are obese than BMI-matched individuals without T2DM. “Building on our 2013 paper, we hypothesized that the microbiota might form


metabolites that can affect insulin sensitivity,” explains Bäckhed. “To address this question, we performed metabolomics on the blood from the portal vein of individuals with T2DM who were


obese and individuals who were obese without T2DM.” This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54


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Koh, A. et al. Microbially produced imidazole propionate impairs insulin signaling through MTORC1. _Cell_. 175, 947–961.e17 (2018) Article  CAS  Google Scholar  Download references AUTHOR


INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Endocrinology http://www.nature.com/nrendo/ Alan Morris Authors * Alan Morris View author publications You can also search for this


author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Alan Morris. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Morris, A. Microbial


metabolite linked to T2DM. _Nat Rev Endocrinol_ 15, 3 (2019). https://doi.org/10.1038/s41574-018-0128-8 Download citation * Published: 08 November 2018 * Issue Date: January 2019 * DOI:


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