Hepatitis A virus infection | Nature Reviews Disease Primers

Hepatitis A is a vaccine-preventable infection caused by the hepatitis A virus (HAV). Over 150 million new infections of hepatitis A occur annually. HAV causes an acute inflammatory reaction

in the liver that usually resolves spontaneously without chronic sequelae. However, up to 20% of patients experience a prolonged or relapsed course and 25 countries worldwide have

implemented such programmes, resulting in a reduction in the incidence of HAV infection. Improving hygiene and sanitation, rapid identification of outbreaks and fast and accurate

intervention in outbreak control are essential to reducing HAV transmission.

Introduction (P.V.D. and D.S.); Epidemiology (P.V.D., D.S. and A.G.); Mechanisms/pathophysiology (R.M.P., Z.F. and D.S.); Diagnosis, screening and prevention (P.V.D., D.S., A.G. and F.C.);

Management (D.S. and A.G.); Quality of life (P.V.D. and D.S.); Outlook (P.V.D., D.S., A.G., F.C., R.M.P. and Z.F.); Overview of Primer (P.V.D. and D.S.).

Nature Reviews Disease Primers thanks R. Aggarwal, H. Askling, G. Dusheiko, S. Lemon, Y. Li, L. Mak and M. Yuen for their contribution to the peer review of this work.

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