Lipid metabolism in peripartum cardiomyopathy


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Access through your institution Buy or subscribe Pathways related to lipid metabolism are dysregulated in cardiomyocytes in women with peripartum cardiomyopathy (PPCM), according to a new


study. Cardiomyocytes obtained from induced pluripotent stem cells (iPSC-CMs) derived from two patients with PPCM and from two healthy individuals were subjected to simulated


pregnancy-associated wall stress in vitro. RNA sequencing and gene ontology analyses indicated that pathways related to lipid metabolism were aberrantly regulated in static and stretched


PPCM iPSC-CMs compared with healthy static iPSC-CMs. Healthy iPSC-CMs had adequate metabolic plasticity via activation of glucose utilization in response to inhibition of lipid metabolism,


but this metabolic switch was impaired in PPCM iPSC-CMs. The findings were validated in an established mouse model of PPCM. Taken together, this study suggests that metabolic regulation is


an important factor for PPCM susceptibility. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other


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are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Hoes, M.


F. et al. Human iPSC-derived cardiomyocytes of peripartum patients with cardiomyopathy reveal aberrant regulation of lipid metabolism. _Circulation_ 142, 2288–2291 (2020) Article  CAS 


Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Cardiology http://www.nature.com/nrcardio/ Irene Fernández-Ruiz Authors * Irene


Fernández-Ruiz View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Irene Fernández-Ruiz. RIGHTS AND PERMISSIONS


Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fernández-Ruiz, I. Lipid metabolism in peripartum cardiomyopathy. _Nat Rev Cardiol_ 18, 150 (2021).


https://doi.org/10.1038/s41569-020-00496-y Download citation * Published: 21 December 2020 * Issue Date: March 2021 * DOI: https://doi.org/10.1038/s41569-020-00496-y SHARE THIS ARTICLE


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