Liver metastases cultivate an immune desert

Access through your institution Buy or subscribe The liver is a frequent site of metastasis; however, it is an immune tolerant organ, characterized by T cell anergy and immunosuppressive

signals. Yu and Green et al. therefore set out to investigate the impact of the immunosuppressive liver microenvironment on systemic immunity and response to immunotherapy. To explore the

mechanisms behind these clinical outcomes, the authors generated a mouse model of liver metastasis, whereby mice harboured subcutaneous primary tumours derived from immunotherapy-responsive

MC38 colorectal cancer cells, and liver metastases were seeded by intrahepatic or intrasplenic injection. A lung metastasis mouse model was generated in a similar way. Following anti-PDL1

treatment, mice with only subcutaneous tumours showed robust CD8+ T cell infiltration and tumour volume reduction. This response was completely abrogated in mice with liver metastases, while

those with lung metastases still responded. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other

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are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Yu, J.

et al. Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination. _Nat. Med._ 27, 152–164 (2021) Article  CAS  Google Scholar  Download references AUTHOR

INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Cancer http://www.nature.com/nrc/ Karen O’Leary Authors * Karen O’Leary View author publications You can also search for this author

inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Karen O’Leary. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE O’Leary, K. Liver

metastases cultivate an immune desert. _Nat Rev Cancer_ 21, 143 (2021). https://doi.org/10.1038/s41568-021-00338-0 Download citation * Published: 05 February 2021 * Issue Date: March 2021 *

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