A framework for designing delivery systems

ABSTRACT The delivery of medical agents to a specific diseased tissue or cell is critical for diagnosing and treating patients. Nanomaterials are promising vehicles to transport agents that

include drugs, contrast agents, immunotherapies and gene editors. They can be engineered to have different physical and chemical properties that influence their interactions with their

biological environments and delivery destinations. In this Review Article, we discuss nanoparticle delivery systems and how the biology of disease should inform their design. We propose

developing a framework for building optimal delivery systems that uses nanoparticle–biological interaction data and computational analyses to guide future nanomaterial designs and delivery

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BEING VIEWED BY OTHERS ENGINEERING PRECISION NANOPARTICLES FOR DRUG DELIVERY Article 04 December 2020 THE ANCILLARY EFFECTS OF NANOPARTICLES AND THEIR IMPLICATIONS FOR NANOMEDICINE Article

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(2016). Google Scholar  Download references ACKNOWLEDGEMENTS W.C.W.C. acknowledges the Canadian Institute of Health Research (CIHR, FDN-159932; MOP-130143), Natural Sciences and Engineering

Research Council of Canada (NSERC, 2015–06397), Canadian Research Chairs program (950–223824), Collaborative Health Research Program (CPG-146468) and Canadian Cancer Society (705185–1) for

funding support. We also acknowledge CIHR (W.P., B.O.), Vanier Canada Graduate Scholarships (B.O.), Ontario Graduate Scholarship (W.P., B.O.), NSERC (B.R.K., W.N.), Barbara and Frank

Milligan (W. P.), Wildcat Foundation (B.R.K., W.N.), Jennifer Dorrington Award (B.R.K.), Royal Bank of Canada and Borealis AI (B.R.K.), Frank Fletcher Memorial Fund (B.O.), John J. Ruffo

(B.O.), Cecil Yip family (W.P., B.R.K., B.O., W.N.) and McLaughlin Centre for MD/PhD studentships (B.O.) for financial support. The authors thank S. Sindhwani, J. Ngai, J. L. Y. Wu, and Z.

Sepahi for manuscript revisions. AUTHOR INFORMATION Author notes * These authors contributed equally: Wilson Poon, Benjamin R. Kingston. AUTHORS AND AFFILIATIONS * Institute of Biomedical

Engineering, University of Toronto, Toronto, Ontario, Canada Wilson Poon, Benjamin R. Kingston, Ben Ouyang, Wayne Ngo & Warren C. W. Chan * Terrence Donnelly Centre for Cellular &

Biomolecular Research, University of Toronto, Toronto, Ontario, Canada Wilson Poon, Benjamin R. Kingston, Ben Ouyang, Wayne Ngo & Warren C. W. Chan * MD/PhD Program, University of

Toronto, Toronto, Ontario, Canada Ben Ouyang * Department of Chemical Engineering & Applied Chemistry, University of Toronto, Toronto, Ontario, Canada Warren C. W. Chan * Department of

Materials Science & Engineering, University of Toronto, Toronto, Ontaro, Canada Warren C. W. Chan * Department of Chemistry, University of Toronto, Toronto, Ontario, Canada Warren C. W.

Chan Authors * Wilson Poon View author publications You can also search for this author inPubMed Google Scholar * Benjamin R. Kingston View author publications You can also search for this

author inPubMed Google Scholar * Ben Ouyang View author publications You can also search for this author inPubMed Google Scholar * Wayne Ngo View author publications You can also search for

this author inPubMed Google Scholar * Warren C. W. Chan View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Warren C.

W. Chan. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to

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B. _et al._ A framework for designing delivery systems. _Nat. Nanotechnol._ 15, 819–829 (2020). https://doi.org/10.1038/s41565-020-0759-5 Download citation * Received: 08 April 2020 *

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