Dual-mechanism antibiotics | Nature Microbiology

feature-image

Play all audios:

Loading...

A dual-mechanism compound with antibacterial activity that targets both folate metabolism and membrane integrity, with a favourable resistance profile in vitro, is identified by screening a


small molecule library. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution RELEVANT ARTICLES Open Access articles citing


this article. * NOVEL TETRACYCLINE HYBRIDS: SYNTHESIS, CHARACTERIZATION, DOCKING STUDIES AND IN-VITRO EVALUATION OF ANTIBACTERIAL ACTIVITY * Mansi Shah * , Bhanubhai Suhagia *  … Arpit


Patwari _Future Journal of Pharmaceutical Sciences_ Open Access 15 January 2025 * SYNERGISTIC ANTIBACTERIAL EFFECT OF COPPER AND SILVER NANOPARTICLES AND THEIR MECHANISM OF ACTION * Grigory


Vasiliev * , Anna-Liisa Kubo *  … Olesja Bondarenko _Scientific Reports_ Open Access 06 June 2023 ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature Portfolio


journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Learn more Subscribe to this journal Receive 12 digital issues and online access to articles


$119.00 per year only $9.92 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are


calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Wang, K. K. et al. _Mol.


Biol. Evol._ 33, 492–500 (2016). Article  CAS  Google Scholar  * Martin, J. K. II et al. _Cell_ 181, 1518–1532 (2020). Article  CAS  Google Scholar  * Bremner, J. B., Ambrus, J. I. &


Samosorn, S. _Curr. Med. Chem._ 14, 1459–1477 (2007). Article  CAS  Google Scholar  * Jubeh, B., Breijyeh, Z. & Karaman, R. _Molecules_ 25, 1543 (2020). Article  CAS  Google Scholar  *


Page, M. G. P. _Clin. Infect. Dis._ 69 (SUPPL. 7), S529–S537 (2019). Article  Google Scholar  * Gupta, V. & Datta, P. _Indian J. Med. Res._ 149, 97–106 (2019). Article  Google Scholar  *


Liu, L. et al. _Molecules_ 24, 1641 (2019). Article  Google Scholar  * Ma, Z. & Lynch, A. S. _J. Med. Chem._ 59, 6645–6657 (2016). Article  CAS  Google Scholar  * Domalaon, R., Idowu,


T., Zhanel, G. G. & Schweizer, F. _Clin. Microbiol. Rev._ 31, e00077-17 (2018). Article  Google Scholar  * Parkes, A. L. & Yule, I. A. _Expert Opin. Drug Discov._ 11, 665–680 (2016).


Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Center for Anti-Infective Agents, Vienna, Austria Ursula Theuretzbacher Authors * Ursula


Theuretzbacher View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Ursula Theuretzbacher. ETHICS DECLARATIONS


COMPETING INTERESTS The author declares no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Theuretzbacher, U. Dual-mechanism


antibiotics. _Nat Microbiol_ 5, 984–985 (2020). https://doi.org/10.1038/s41564-020-0767-0 Download citation * Published: 24 July 2020 * Issue Date: August 2020 * DOI:


https://doi.org/10.1038/s41564-020-0767-0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not


currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative