The gains from breaking symmetry

All-carbon quaternary centres are challenging targets in organic synthesis. Now, the development of a zinc-catalysed desymmetrization method enables the synthesis of chiral alcohols with

all-carbon quaternary centres by the selective reduction of symmetrical α,α-disubstituted malonates. Access through your institution Buy or subscribe This is a preview of subscription

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* Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Mikami, K. & Lautens, M. (eds) _New Frontiers in Asymmetric Catalysis_ (Wiley-VCH,

2007). * Todd, M. (ed.) _Separation of Enantiomers_ (Wiley-VCH, 2014). * Zeng, X.-P., Cao, Z.-Y., Wang, Y.-H., Zhou, F. & Zhou, J. _Chem. Rev._ 116, 7330–7396 (2016). Article  CAS 

Google Scholar  * Xu, P. & Huang, Z. _Nat. Chem._ https://doi.org/10.1038/s41557-021-00715-0 (2021). Article  PubMed  Google Scholar  * García-Urdiales, E., Alfonso, I. & Gotor, V.

_Chem. Rev._ 105, 313–354 (2005). Article  Google Scholar  * Provencher, L. & Jones, J. B. _J. Org. Chem._ 59, 2729–2732 (1994). Article  CAS  Google Scholar  * Mimoun, H., de Saint

Laumer, J. Y., Giannini, L., Scopelliti, R. & Floriani, C. _J. Am. Chem. Soc._ 121, 6158–6166 (1999). Article  CAS  Google Scholar  * Trost, B. M., Hung, C.-I. (J.) & Mata, G.

_Angew. Chem. Int. Ed._ 59, 4240–4261 (2020). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Chemistry, Adam Mickiewicz

University, Poznań, Poland Jadwiga Gajewy & Marcin Kwit Authors * Jadwiga Gajewy View author publications You can also search for this author inPubMed Google Scholar * Marcin Kwit View

author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Marcin Kwit. ETHICS DECLARATIONS COMPETING INTERESTS The authors

declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Gajewy, J., Kwit, M. The gains from breaking symmetry. _Nat. Chem._ 13,

623–624 (2021). https://doi.org/10.1038/s41557-021-00731-0 Download citation * Published: 10 June 2021 * Issue Date: July 2021 * DOI: https://doi.org/10.1038/s41557-021-00731-0 SHARE THIS

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