Mitotic lethality prevents inflammation

A study now finds that, after DNA damage, DNA repair by homologous recombination drives non-immunogenic cell death during mitosis. Loss of homologous recombination allows cells to pass

through mitosis, but drives interphase death and inflammation. This suggests a dichotomy between immunogenic and non-immunogenic cell-death modes, with biomedical potential. Access through

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_bioRxiv_ https://doi.org/10.1101/2024.05.13.593978 (2024). Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Cancer Biology, The Institute of Cancer Research,

London, UK Christian Zierhut * Institute for Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria Andreas Villunger * The Research Center for Molecular

Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria Andreas Villunger Authors * Christian Zierhut View author publications You can also search for this author inPubMed 

Google Scholar * Andreas Villunger View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to Christian Zierhut or Andreas

Villunger. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Zierhut,

C., Villunger, A. Mitotic lethality prevents inflammation. _Nat Cell Biol_ 27, 7–8 (2025). https://doi.org/10.1038/s41556-024-01529-1 Download citation * Published: 14 January 2025 * Issue

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