Yap/taz phase separation for transcription

YAP and TAZ, paralogous mammalian genes, act as the key transcriptional effectors of the Hippo pathway. Two recent reports show that both YAP and TAZ form liquid–liquid phase-separated

bodies that promote gene transcription by engaging in super-enhancers. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution

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_Science_ 296, 913–916 (2002). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pharmacology and Moores Cancer Center,

University of California, San Diego, La Jolla, CA, USA J. Matthew Franklin & Kun-Liang Guan Authors * J. Matthew Franklin View author publications You can also search for this author

inPubMed Google Scholar * Kun-Liang Guan View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Kun-Liang Guan. ETHICS

DECLARATIONS COMPETING INTERESTS K.L.G. is a cofounder of and has equity interest in Vivace Therapeutics. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE

Franklin, J.M., Guan, KL. YAP/TAZ phase separation for transcription. _Nat Cell Biol_ 22, 357–358 (2020). https://doi.org/10.1038/s41556-020-0498-8 Download citation * Published: 23 March

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