Translating clinical findings to the legal norm: the defendant’s insanity assessment support scale (diass)

feature-image

Play all audios:

Loading...

ABSTRACT Insanity definition and the threshold for satisfying its legal criteria tend to vary depending on the jurisdictions. Yet, in Western countries, the legal standards for insanity


often rely on the presence of cognitive and/or volitional impairment of the defendant at crime time. Despite some efforts having been made to guide and structure criminal responsibility


evaluations, a valid instrument that could be useful to guide forensic psychiatrists’ criminal responsibility assessments in different jurisdictions is lacking. This is a gap that needs to


be addressed, considering the significant forensic and procedural implications of psychiatric evaluations. In addition, differences in methodology used in insanity assessments may also have


consequences for the principle of equal rights for all citizens before the law, which should be guaranteed in the European Union. We developed an instrument, the Defendant’s Insanity


Assessment Support Scale (DIASS), which can be useful to support, structure, and guide the insanity assessment across different jurisdictions, in order to improve reliability and consistency


of such evaluations. SIMILAR CONTENT BEING VIEWED BY OTHERS VALIDATION OF A NEW INSTRUMENT TO GUIDE AND SUPPORT INSANITY EVALUATIONS: THE DEFENDANT’S INSANITY ASSESSMENT SUPPORT SCALE


(DIASS) Article Open access 22 March 2022 ACQUIRED PEDOPHILIA: INTERNATIONAL DELPHI-METHOD-BASED CONSENSUS GUIDELINES Article Open access 18 January 2023 A RAPID NARRATIVE REVIEW OF THE


CLINICAL EVOLUTION OF PSYCHEDELIC TREATMENT IN CLINICAL TRIALS Article Open access 02 July 2024 INTRODUCTION Insanity evaluations are among the most complex and controversial mental health


assessments that psychiatrists and psychologists perform1,2. A forensic evaluator is expected to perform a retrospective evaluation of the defendant’s state of mind at the time of crime, to


ascertain the presence of a mental disease or defect and to further verify the existence of a possible relationship between that state of mind and the criminal behavior. In case such a


relationship exists, its impact on the defendant’s responsibility is further evaluated, and the conclusions will be used by the judge to assess the defendant’s legal responsibility.


Depending on the jurisdiction, the psychiatrist’s task and the threshold for satisfying legal criteria for insanity, as well as the definition of insanity itself, may vary. In Western


countries, the legal standards for insanity often rely on the presence of cognitive and/or volitional impairment of the defendant at crime time3. In the Anglo-American systems the most


acknowledged standards are the M’Naghten Rule (M’Naghten’s Case, 10 Cl. & Fin. 200, 8 Eng. Rep. 718 (H.L. 1843)), and the The Model Penal Code’s test, also known as the American Law


Institute (ALI) standard4. The M’Naghten Rule focuses on the cognitive component, and states that a defendant is not found responsible if, due to a mental disorder, he did “_not know the


nature and quality of the act he was doing; or if he did know it, that he did not know what he was doing was wrong_”. The Model Penal Code, meanwhile, comprises a cognitive as well as a


behavioral component, and states that “_a person is not responsible for criminal conduct if at the time of such conduct as a result of mental disease or defect he lacks substantial capacity


either to appreciate the criminality (wrongfulness) of his conduct or to conform his conduct to the requirements of the law”_. In those cases where insanity is ascertained, the defendant


would be adjudicated either not guilty by reason of insanity (NGRI or NGI) or guilty but not criminally responsible, depending on the legal system5. A negative attitude toward the insanity


defense has been reported, and it has been found to be associated with juror judgments6,7. A common perception by the lay public is that the insanity defense is overused and might allow


criminals to avoid punishment, a belief that appears to entail an implicit distrust regarding the underlying forensic mental health evaluations6,7,8,9,10. Such a perception, however, might


be inaccurate in view of the existing data. For instance, in a dated pioneering study, it was found that insanity pleas are raised in about 1% of felony cases and proving successful only in


about 28% of those cases11. Nevertheless, a more recent study from our group showed 42% of insanity judgments among evaluated defendants12. These differences are mainly due to different


legal thresholds for admitting psychiatric evidence in criminal cases that vary broadly. A possible source of distrust lies however in the frequent disagreement among experts, with a recent


meta-analysis showing that forensic evaluators disagreed 25–35% of the time13. This may be associated with the intrinsic limits of psychiatric diagnosis, the different and non-standardized


evaluation methodologies2,14, and with the longitudinal variability of psychiatric symptoms, implying that evaluations carried out at different times can lead to different conclusions on the


same case. As a consequence, expert evaluation has often been considered a “battle of the experts” rather than accurate, objective, and reliable testimony on the defendant’s criminal


responsibility—in particular in adversarial legal systems15. The absence of biological markers available to guide forensic psychiatric evaluations, and the relative scarcity of reliable and


diagnostic tools to guide such assessments, might also account for discrepancies between expert testimonies. In addition, the paucity of research on insanity evaluations implies poor


empirical support underlying such assessment2. Finally, the dialectic of the criminal trial must be acknowledged, where different parties plead their case, which entails the possibility of


different opinions, which the court or jury weighs. At the same time, we should be cautious in interpreting this finding13, since this analysis concerns those cases that went to trial. In


some jurisdictions, when the experts agree, the cases may not go to trial. Efforts have been made to guide and structure criminal responsibility evaluations, for example the American Academy


of Psychiatry and Law published practice guidelines for insanity defense evaluations5, which mainly deal with the steps and information needed to perform them. Among the forensic assessment


instruments to assist the criminal responsibility evaluation, are the “Mental State at the Time of the Offense Screening Evaluation” (MSE)16 and the “Rogers Criminal Responsibility


Assessment Scales” (R-CRAS)17,18. The MSE is a semi-structured interview to screen out defendants whose criminal conduct clearly was not caused by significant mental abnormality19. The


R-CRAS was developed from the American Law Institute’s criteria for the insanity defense, and is composed of 25 items organized into 5 scales assessing: reliability (including malingering),


organic factors, psychopathology, cognitive control, and behavioral control18. In addition, some theoretical models have been proposed to guide the insanity evaluation20,21,22,23,24.


However, to the best of our knowledge, a valid instrument that could be useful to guide mental health experts in criminal responsibility assessments in different jurisdictions, is lacking.


This is a lacuna that deserves to be addressed, considering the significant forensic and procedural implications of psychiatric evaluations. Basically, two types of errors may occur: * 1. An


(insane) defendant who is mistakenly considered to be accountable for a crime, despite the presence and influence of a significant psychiatric disorder on his criminal behavior, will find


himself/herself punished for a crime for which he should not be held responsible. No justice is being done. Moreover, he could enter the penitentiary system with fewer possibilities to be


treated for his disease. * 2. A (sane) defendant who is erroneously acquitted because considered insane at the moment of the crime will not be punished for a crime he/she should have been


held responsible for. No justice is being done. In addition, he/she will enter a forensic psychiatric system, by using treatment resources that are usually limited. Differences in


methodology used in insanity assessments may also have consequences for the principle of equal rights for all citizens before the law, which should be guaranteed in the European Union.


Furthermore, the availability of a tool that can be used in forensic psychiatric practice could facilitate the exchange of empirical data in research across different jurisdictions and


disciplines, thus implementing the evidence that could be of empirical support. Some efforts to shed light on the processes underlying forensic evaluators’ decision-making during the


insanity assessment have already been made12,25,26. The aim of this study was to develop the Defendant’s Insanity Assessment Support Scale (DIASS), an instrument, which can be useful to


support, structure, and guide the insanity assessment across different jurisdictions, in order to improve reliability and consistency of such evaluations. METHODS THE DEVELOPMENT OF THE


DEFENDANT’S INSANITY ASSESSMENT SUPPORT SCALE (DIASS) The authors initially reviewed insanity criteria applied in different countries3,5,27,28,29. In the second phase, the authors used the


clinical model of competence to consent to treatment, with some adaptations to the legal field, as a conceptual framework to guide the evaluations of insanity24,28. The model refers to


capacity to consent to treatment as a multidimensional construct that relies on several abilities, i.e., understanding information, evaluating information, rational reasoning, and the


capacity to express a clear choice30. It was used because it proved to be a theoretical model on decision-making with wide experimental empirical evidence on patients, specifically on


patients affected by mental disorders31,32,33,34,35,36,37,38 and cognitive dysfunctions28,39,40,41,42,43,44,45. This decision-making capacity model could straightforwardly be adapted to the


forensic evaluation of criminal responsibility regarding the understanding dimension (wrongfulness of the act: legal and moral aspects of the act), the appreciation dimension (the nature of


and possible options in the situation; e.g., in terms of threat, danger, and risks), and the reasoning dimension (concerning consequences in terms of pros and cons, etc.). The adaptation of


the “expression of a choice” dimension to the legal field, required a deep revision of the original scale’s concept and the introduction of a “behavioral component”. Despite the fact that


not all legal systems consider the behavioral dimension as relevant for assessing criminal responsibility, inhibitory control and executive functioning often play a significant role in the


forensic evaluations. This view is also supported by neuroscientific studies showing the presence of cerebral abnormalities in violent offenders, especially prefrontal


dysfunctions46,47,48,49,50,51,52,53. To what extent these data can be relevant in a forensic psychiatric setting is still a matter of discussion, despite the fact that a neurolaw perspective


is receiving growing attention in the last few years54. To integrate both cognitive and control issues, we have structured the Defendant’s Insanity Assessment Support Scale (DIASS), based


on two components: the first component concerns epistemic factors examining the defendant’s knowledge/understanding and appreciating at the time of the offense. The second component concerns


behavioral control-related factors, referring to the defendant’s reasoning processes and control of voluntary motor activity, at crime time. The preliminary DIASS was then reviewed by


experts in three relevant fields: forensic psychiatry (JH), philosophy (SR), and law (GD). The DIASS is shown in Supplementary Appendix. THE DEFENDANT’S INSANITY ASSESSMENT SUPPORT SCALE


(DIASS) The DIASS has been developed based on a wide view of (competent) decision-making, which reflects core issues relevant to legal insanity in many jurisdictions. The DIASS (see


Supplementary Appendix) comprises nine binary items (present/absent) grouped into four dimensions: “Knowledge/understanding of the crime” (3 items), “Appreciating of the crime” (1 item),


“Reasoning” (3 items), and “Control of voluntary motor activity” (2 items). The first two dimensions refer to the “Epistemic component”, while the third and fourth dimensions refer to the


“Control component”. These dimensions refer to the mental state of the accused at the time of the crime. At the end of the scale, there is a box referring to the final judgments on the


Epistemic and Control components, which are scored on a three-point scale (intact, partially compromised, and compromised). After having analyzed each subdimension of the Epistemic component


(in those countries based on the M’Naghten rule) or of both the Epistemic and Control components (Model Penal Code), the evaluator can indicate their total or partial score, in order to


reach his/her final judgment regarding the defendant’s criminal responsibility. The DIASS is an instrument that should be used only after having examined all the legal and health


documentation of the defendant, as well as after having carried out the clinical evaluation. It is basically meant to apply the clinical findings to the relevant law in the jurisdiction


where the trial is taking place. All the four dimensions of the DIASS can be influenced by psychopathological symptoms, including thought disorders (disorders of the form of thought such as


pressure of thought, fight of ideas and logorrhea, circumstantiality, perseveration, thought blocking, and disorders of the content of thought such as delusions), perceptual disturbances


(such as illusions and hallucinations), mood alterations (such as depression, excitement, and dysphoria), and cognitive dysfunction (such as attention deficits, memory dysfunctions, impaired


reasoning abilities, and executive dysfunctions) (see Fig. 1). For example, a person affected by a paranoid delusion may commit a crime believing that his actions are acts of self-defense,


proportionate to the threat (in this case the thought disorder has an impact on the knowledge–understanding of the nature (wrongfulness) of the act). A subject hearing commanding voices from


God may believe that his crime is justified, despite it being against the objective moral standard (in this case the perceptual disturbances affect the appreciation of the subjective moral


standard). An individual affected by a bipolar disorder in a manic phase may not have the capacity to properly reason about the consequences of his actions in terms of pros and cons (in this


case the mood disorder influences the reasoning dimension). Finally, a person affected by a frontotemporal dementia, may have no capacity to inhibit his unlawful action (in this case the


cognitive disfunction has an impact on the control of voluntary motor activity). However, among these four groups of psychopathological symptoms, we believe that the cognitive dysfunction


deserves a consideration on its own; in those cases in which the subject’s IQ is particularly low or the individual is affected by moderate or severe dementia, it can in fact have an


influence on all the four dimensions of the DIASS. Regarding the applicability of the DIASS in different countries, as legal insanity standards are likely to refer not to all of these


components, depending on the specific criteria in a particular jurisdiction, the relevant ones can be selected and evaluated. For example, if the M’Naghten Rule applies, the element of


knowledge would be relevant. If the Model Penal Code test is in use, the elements of appreciation (one of the epistemic components) and control (behavioral control) are relevant. The


evaluator should use the components of the DIASS that are reflected in the legal criterion relevant to the particular jurisdiction in which he or she evaluates a defendant. For those legal


systems where no explicit criteria have been formulated to determine the legally relevant impact of a disorder, such as the Netherlands, we deem that it may be helpful to consider all the


components of this tool in order to arrive at an opinion about a defendant’s legal insanity. The insanity criteria require a mental illness, or a physical disease that has an impact on the


defendants’ mental functioning. Different terms have been used in the legal tests: for instance, M’Naghten refers to “disease of the mind”, while the Model Penal Code standard mentions a


“mental disease or defect”, the Italian penal code refers to “mental infirmity”. Other standards in different jurisdictions may use alternative languages and terms. The DIASS does not define


the criteria for that component of the insanity standard, as it focuses on a functional approach. Finally, even though the tool is developed to support the expert’s evaluations of legal


insanity, the ultimate decision is—depending on the jurisdiction—up to the judge or jury. CONCLUSION The DIASS has been developed as a guide and a support tool to promote the quality and


transparency of insanity evaluation. It is meant to facilitate the application of the clinical findings to the relevant legal context of the jurisdiction where the trial is taking place and


it can be used to formulate one’s expert opinion. Depending on the insanity criteria that are relevant in a specific jurisdiction, the evaluator can choose whether to use only one or both


the DIASS components. The instrument represents a step toward some standardization that will hopefully promote the exchange of ideas and research findings across jurisdictions and


disciplines. This would be a valuable development for an area that is of considerable medical, legal, and societal importance, but that regrettably continues to be understudied. The use of


the DIASS in forensic psychiatric evaluations can be an initial step toward a reduction of the heterogeneity in methodology between countries, which is in line with the principle of equal


rights for all citizens before the law, which should be guaranteed in the European Union. Finally, the proposed instrument is compatible with neuroscience, as the evaluation of the epistemic


and behavioral components can be informed by a growing body of neuroscientific data. This will make it possible to perform assessments that are supported by neuroscientific views and


findings. REFERENCES * Gardner, B. O., Murrie, D. C. & Torres, A. N. Insanity findings and evaluation practices: A state-wide review of court-ordered reports. _Behav. Sci. Law._ 36,


303–316 (2018). Article  Google Scholar  * Gowensmith, W. N., Murrie, D. C. & Boccaccini, M. T. How reliable are forensic evaluations of legal sanity? _Law Hum. Behav._ 37, 98–106


(2013). Article  PubMed  Google Scholar  * Simon, R. J. & Ahn‐Redding, H. _The Insanity Defense, The World Over_ (Bowman & Littlefields, Plymouth, 2006). * Americal Law Institute.


_Model Penal Code_ (American Law Institute, Philadelphia, 1962). * American Academy of Psychiatry and the Law (AAPL). AAPL practice guideline for forensic psychiatric evaluation of


defendants raising the insanity defense. _J. Am. Acad. Psychiatry Law._ 42, S3–S76 (2014). PubMed  Google Scholar  * Skeem, J. L. & Golding, S. L. Describing jurors’ personal conceptions


of insanity and their relationship to case judgments. _Psychol. Public Policy Law._ 7, 561–621 (2001). Article  Google Scholar  * Skeem, J. L., Louden, J. E. & Evans, J. Venirepersons’s


attitudes toward the insanity defense: developing, refining, and validating a scale. _Law Hum. Behav._ 28, 623–648 (2004). Article  PubMed  Google Scholar  * Maeder, E. M. & Fenwick, K.


L. The more you know: educating jurors about the not criminally responsible by reason of mental disorder (NCRMD) defense. Poster session presented at the 2nd North American Correctional and


Criminal Justice Psychology/Canadian Psychological Association Conference; 2011 June 2–4, Toronto, ON (2011). * Silver, E., Cirincione, C. & Steadman, H. J. Demythologizing inaccurate


perceptions of the insanity defense. _Law Hum. Behav._ 18, 63–70 (1994). Article  Google Scholar  * Vitacco, M. J. et al. Measuring attitudes toward the insanity defense in venirepersons:


refining the ida-r in the evaluation of juror bias. _Int. J. Forensic Ment. Health_ 8, 62–70 (2009). Article  Google Scholar  * Callahan, L. A., Steadman, H. J., McGreevy, M. A. &


Robbins, P. C. The volume and characteristics of insanity defense pleas: an eight-state study. _Bull. Am. Acad. Psychiatry Law._ 19, 331–338 (1991). CAS  PubMed  Google Scholar  *


Mandarelli, G. et al. The factors associated with forensic psychiatrists’ decisions in criminal responsibility and social dangerousness evaluations. _Int. J. Law Psychiatry_ 66, 101503


(2019). Article  PubMed  Google Scholar  * Guarnera, L. A. & Murrie, D. C. Field reliability of competency and sanity opinions: a systematic review and metaanalysis. _Psychol. Assess._


29, 795–818 (2017). Article  PubMed  Google Scholar  * Kacperska, I., Heitzman, J., Bak, T., Lesko, A. W. & Opio, M. Reliability of repeated forensic evaluations of legal sanity. _Int.


J. Law Psychiatry_ 44, 24–29 (2016). Article  PubMed  Google Scholar  * Hans, V. P. An analysis of public attitudes toward the insanity defense. _Criminology_ 24, 393–414 (1986). Article 


Google Scholar  * Slobogin, C., Melton, G. B. & Showalter, C. R. The feasibility of a brief evaluation of mental state at the time of the offense. _Law Hum. Behav._ 8, 305–320 (1984).


Article  Google Scholar  * Rogers, R., Dolmetsch, R. & Cavanaugh, J. L. An empirical approach to insanity evaluations. _J. Clin. Psychol._ 37, 683–687 (1981). Article  CAS  PubMed 


Google Scholar  * Rogers, R., Wasyliw, O. E. & Cavanaugh, J. L. Evaluating insanity. A study of construct validity. _Law Hum. Behav._ 8, 293–303 (1984). Article  Google Scholar  *


Weiner, I. B. & Otto, R. K. _The Handbook of Forensic Psychology_. _Fourth Edition_. (Wiley, New York, NY, 2013). Google Scholar  * Kalis, A. & Meynen, G. Mental disorder and legal


responsibility: the relevance of stages of decision making. _Int J. Law Psychiatry_ 37, 601–608 (2014). Article  PubMed  Google Scholar  * Meynen, G. Free will and psychiatric assessments of


criminal responsibility: a parallel with informed consent. _Med Health Care Philos._ 13, 313–320 (2010). Article  PubMed  PubMed Central  Google Scholar  * Meynen, G. Free will and mental


disorder: exploring the relationship. _Theor. Med. Bioeth._ 31, 429–443 (2010). Article  PubMed  PubMed Central  Google Scholar  * Meynen, G. Autonomy, criminal responsibility, and


competence. _J. Am. Acad. Psychiatry Law._ 39, 231–236 (2011). PubMed  Google Scholar  * Parmigiani, G. et al. Free will, neuroscience, and choice: towards a decisional capacity model for


insanity defense evaluations. _Riv. Psichiatr._ 52, 9–15 (2017). PubMed  Google Scholar  * Beckham, J. C., Annis, L. V. & Gustafsont, D. J. Decision making and examiner bias in forensic


expert recommendations for not guilty by reason of insanity. _Law Hum. Behav._ 13, 79–87 (1989). Article  Google Scholar  * Homant, R. J. & Kennedy, D. B. Judgment of legal insanity as a


function of attitude toward the insanity defense. _Int J. Law Psychiatry_ 8, 67–81 (1986). Article  CAS  PubMed  Google Scholar  * Bertolino, M. _L_ ’_imputabilità e il vizio di mente nel


sistema penale_. (Giuffré, Milano, 1990). * Meynen, G. _Legal Insanity: Explorations in Psychiatry, Law, and Ethics_ (Springer, 2016). * Ferracuti, S. et al. Evolution of forensic psychiatry


in Italy over the past 40 years (1978–2018). _Int J. Law Psychiatry_ 62, 45–49 (2019). Article  PubMed  Google Scholar  * Appelbaum, P. S. Clinical practice. Assessment of patients’


competence to consent totreatment. _N. Engl. J. Med._ 357, 1834–1840 (2007). Article  CAS  PubMed  Google Scholar  * Cairns, R. et al. Reliability of mental capacity assessments in


psychiatric in-patients. _Br. J. Psychiatry_ 187, 372–378 (2005). Article  PubMed  Google Scholar  * Candilis, P. J., Fletcher, K. E., Geppert, C. M., Lidz, C. W. & Appelbaum, P. S. A


direct comparison of research decision-making capacity: schizophrenia/schizoaffective, medically ill, and non-ill subjects. _Schizophr. Res._ 99, 350–358 (2008). Article  PubMed  PubMed


Central  Google Scholar  * Carabellese, F. et al. Mental capacity e capacity to consent: studio multicentrico in un campione di pazienti ricoverati in TSO. _Riv. Psichiatr._ 52, 67–74


(2017). PubMed  Google Scholar  * Howe, V. et al. Competence to give informed consent in acute psychosis is associated with symptoms rather than diagnosis. _Schizophr. Res._ 77, 211–214


(2005). Article  CAS  PubMed  Google Scholar  * Mandarelli, G. et al. Treatment decision-making capacity in non-consensual psychiatric treatment: a multicentre study. _Epidemiol. Psychiatr.


Sci._ 27, 492–499 (2018). Article  CAS  PubMed  Google Scholar  * Mandarelli, G. et al. Mental capacity in patients involuntarily or voluntarily receiving psychiatric treatment for an acute


mental disorder. _J. Forensic Sci._ 59, 1002–1007 (2014). Article  PubMed  Google Scholar  * Rutledge, E., Kennedy, M., O’Neill, H. & Kennedy, H. G. Functional mental capacity is not


independent of the severity of psychosis. _Int J. Law Psychiatry_ 31, 9–18 (2008). Article  PubMed  Google Scholar  * Stroup, S. et al. Decision-making capacity for research participation


among individuals in the CATIE schizophrenia trial. _Schizophr. Res._ 80, 1–8 (2005). Article  PubMed  Google Scholar  * Koren, D. et al. The neuropsychological basis of competence to


consent in first-episode schizophrenia: a pilot metacognitive study. _Biol. Psychiatry_ 57, 609–616 (2005). Article  PubMed  Google Scholar  * Mandarelli, G. et al. The relationship between


executive functions and capacity to consent to treatment in acute psychiatric hospitalization. _J. Empir. Res. Hum. Res. Ethics_ 7, 63–70 (2012). Article  PubMed  Google Scholar  * Moser, D.


J. et al. Capacity to provide informed consent for participation in schizophrenia and HIV research. _Am. J. Psychiatry_ 159, 1201–1207 (2002). Article  PubMed  Google Scholar  * Palmer, B.


W. & Jeste, D. V. Relationship of individual cognitive abilities to specific components of decisional capacity among middle-aged and older patients with schizophrenia. _Schizophr. Bull._


32, 98–106 (2006). Article  PubMed  Google Scholar  * Palmer, B. W., Dunn, L. B., Depp, C. A., Eyler, L. T. & Jeste, D. V. Decisional capacity to consent to research among patients with


bipolar disorder: comparison with schizophrenia patients and healthy subjects. _J. Clin. Psychiatry_ 68, 689–696 (2007). Article  PubMed  Google Scholar  * Parmigiani, G. et al. Decisional


capacity to consent to clinical research involving placebo in psychiatric patients. _J. Forensic Sci._ 61, 388–393 (2016). Article  PubMed  Google Scholar  * Mandarelli, G. et al. Decisional


capacity to consent to treatment and anaesthesia in patients over the age of 60 undergoing major orthopaedic surgery. _Med. Sci. Law._ 59, 247–254 (2019). Article  Google Scholar  *


Aharoni, E. et al. Neuroprediction of future rearrest. _Proc. Natl Acad. Sci. USA_ 110, 6223–6228 (2013). Article  CAS  PubMed  PubMed Central  Google Scholar  * Bufkin, J. L. &


Luttrell, V. R. Neuroimaging studies of aggressive and violent behavior: current findings and implications for criminology and criminal justice. _Trauma Violence Abus._ 6, 176–191 (2005).


Article  Google Scholar  * Davidson, R. J. Dysfunction in the neural circuitry of emotion regulation—a possible prelude to violence. _Science_ 289, 591–594 (2000). Article  CAS  PubMed 


Google Scholar  * Pietrini, P. & Bambini, V. Homo ferox: the contribution of functional brain studies to understanding the neural bases of aggressive and criminal behavior. _Int. J. Law


Psychiatry_ 32, 259–265 (2009). Article  PubMed  Google Scholar  * Rigoni, D. et al. How neuroscience and behavioral genetics improve psychiatric assessment: report on a violent murder case.


_Front Behav. Neurosci._ 4, 160 (2010). Article  PubMed  PubMed Central  Google Scholar  * Sapolsky, R. M. The frontal cortex and the criminal justice system. _Philos. Trans. R. Soc. Lond.


B Biol. Sci._ 359, 1787–1796 (2004). Article  PubMed  PubMed Central  Google Scholar  * Sartori, G., Scarpazza, C., Codognotto, S. & Pietrini, P. An unusual case of acquired pedophilic


behavior following compression of orbitofrontal cortex and hypothalamus by a Clivus Chordoma. _J. Neurol._ 263, 1454–1455 (2016). Article  PubMed  Google Scholar  * Scarpazza, C., Ferracuti,


S., Miolla, A. & Sartori, G. The charm of structural neuroimaging in insanity evaluations: guidelines to avoid misinterpretation of the findings. _Transl. Psychiatry_ 8, 227 (2018).


Article  CAS  PubMed  PubMed Central  Google Scholar  * Meynen G. Forensic psychiatry and neurolaw: Description, developments, and debates. _Int. J. Law Psychiatry_


https://doi.org/10.1016/j.ijlp.2018.04.005 (2018). Article  PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS We would like to thank Dr. Susanna Radovic, Dr. Jacobus W. Hummelen,


and Dr. Giandomenico Dodaro for their helpful suggestions. All the authors received no financial support for this study; meanwhile part of the research performed by Prof. Gerben Meynen was


funded by a visiting professor stipend from Sapienza University Rome. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Human Neurosciences, “Sapienza” University of Rome, Rome,


Italy Giovanna Parmigiani, Gabriele Mandarelli & Stefano Ferracuti * Section of Criminology and Forensic Psychiatry, University of Bari Aldo Moro, Department of Interdisciplinary


Medicine, Bari, Italy Gabriele Mandarelli & Felice Carabellese * Willem Pompe Institute for Criminal Law and Criminology, Utrecht University, Utrecht, The Netherlands Gerben Meynen *


Faculty of Humanities, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands Gerben Meynen Authors * Giovanna Parmigiani View author publications You can also search for this author


inPubMed Google Scholar * Gabriele Mandarelli View author publications You can also search for this author inPubMed Google Scholar * Gerben Meynen View author publications You can also


search for this author inPubMed Google Scholar * Felice Carabellese View author publications You can also search for this author inPubMed Google Scholar * Stefano Ferracuti View author


publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Giovanna Parmigiani. ETHICS DECLARATIONS CONFLICT OF INTEREST The authors


declare that they have no conflict of interest. ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional claims in published maps and


institutional affiliations. SUPPLEMENTARY INFORMATION APPENDIX A RIGHTS AND PERMISSIONS OPEN ACCESS This article is licensed under a Creative Commons Attribution 4.0 International License,


which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link


to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless


indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or


exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Reprints


and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Parmigiani, G., Mandarelli, G., Meynen, G. _et al._ Translating clinical findings to the legal norm: the Defendant’s Insanity Assessment


Support Scale (DIASS). _Transl Psychiatry_ 9, 278 (2019). https://doi.org/10.1038/s41398-019-0628-x Download citation * Received: 25 January 2019 * Revised: 24 September 2019 * Accepted: 20


October 2019 * Published: 07 November 2019 * DOI: https://doi.org/10.1038/s41398-019-0628-x SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get


shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative