Lung ultrasound score for prediction of surfactant administration in preterm infants with respiratory failure

ABSTRACT OBJECTIVE We investigated the predictive value of a lung ultrasound score (LUS) for surfactant administration in a United States Level 4 Neonatal Intensive Care Unit. STUDY DESIGN

Thirty infants born at <37 weeks gestational age with respiratory distress syndrome associated respiratory failure requiring continuous positive airway pressure were included. A LUS was

obtained within six hours of life. Surfactant administration in the first five days of life was recorded. Receiver operating characteristic (ROC) analysis for LUS and surfactant

administration was performed. RESULTS Median completed gestational age was 33 weeks (31–34 weeks interquartile range) and median birth weight was 2.0 kg (1.5–2.3 kg). LUS for predicting an

initial surfactant dose had an area under the ROC curve of 0.97. A score > 9 provided 100% sensitivity and 91% specificity for predicting administration of an initial surfactant dose.

CONCLUSION A LUS > 9 provided excellent sensitivity and specificity for predicting which infants will receive surfactant for associated respiratory failure. Access through your

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BEING VIEWED BY OTHERS LUNG ULTRASOUND (LUS) AND SURFACTANT TREATMENT: LOOKING FOR THE BEST PREDICTIVE MOMENT Article 23 March 2021 ACCURACY OF LUNG ULTRASOUND IN PREDICTING SUCCESSFUL

EXTUBATION IN PRETERM INFANTS BORN ≤ 25 WEEKS Article 14 January 2025 EARLY ASSESSMENT OF LUNG AERATION USING AN ULTRASOUND SCORE AS A BIOMARKER OF DEVELOPING BRONCHOPULMONARY DYSPLASIA: A

PROSPECTIVE OBSERVATIONAL STUDY Article 14 July 2020 DATA AVAILABILITY The data supporting these findings is not openly available but can be made available by the corresponding author upon

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ACKNOWLEDGEMENTS We would like to thank the University of Connecticut/Connecticut Children’s for supporting this research, the families for agreeing to participate in the study, and the

bedside nursing staff that helped to take care of the enrolled infants. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, University of Connecticut School of Medicine,

Farmington, CT, USA Jacob Kelner & Annmarie Golioto * Division of Neonatology, Connecticut Children’s, Hartford, CT, USA Jacob Kelner & Annmarie Golioto * Division of Pediatric

Radiology, Connecticut Children’s, Hartford, CT, USA Douglas Moote * Division of Pediatric Emergency Medicine, Connecticut Children’s, Hartford, CT, USA Rahul Shah * Health Services Research

Institute, Connecticut Children’s, Hartford, CT, USA Amirul Anuar Authors * Jacob Kelner View author publications You can also search for this author inPubMed Google Scholar * Douglas Moote

View author publications You can also search for this author inPubMed Google Scholar * Rahul Shah View author publications You can also search for this author inPubMed Google Scholar *

Amirul Anuar View author publications You can also search for this author inPubMed Google Scholar * Annmarie Golioto View author publications You can also search for this author inPubMed 

Google Scholar CONTRIBUTIONS JK helped design the study, performed the ultrasounds, acquired the data for analysis, interpreted the data, and assisted in writing the manuscript. DM helped

design the study, performed quality assurance of the ultrasound images, and assisted in writing the manuscript. RS helped design the study, performed quality assurance of the ultrasound

images, and assisted in writing the manuscript. AA helped design the study, performed the statistical analysis, and assisted in writing the manuscript. AG helped design the study,

interpreted the data, and assisted in writing the manuscript. CORRESPONDING AUTHOR Correspondence to Jacob Kelner. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing

interests. ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. RIGHTS AND

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ARTICLE CITE THIS ARTICLE Kelner, J., Moote, D., Shah, R. _et al._ Lung Ultrasound Score for Prediction of Surfactant Administration in Preterm Infants with Respiratory Failure. _J

Perinatol_ 44, 1258–1263 (2024). https://doi.org/10.1038/s41372-024-02090-3 Download citation * Received: 06 February 2024 * Revised: 29 July 2024 * Accepted: 31 July 2024 * Published: 09

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