Is there any true distinction in extreme dipping versus nondipping or dipping phenotype regarding hypertension-mediated organ damage in newly diagnosed and never-treated hypertensive patients?

ABSTRACT Dipping phenomena is defined as nocturnal BP fall >10% during 24-h ambulatory blood pressure (BP) monitoring (ABPM) which carries a favorable cardiovascular risk (CVR) prognosis

due to reduced 24-h hypertension burden. To date, extreme dipping phenotype (defined as BP decrease ≥20%) has led to controversial prognostic results regarding CVR. We aimed to explore

hypertension-mediated organ damage (HMOD) in extreme dippers compared to the other dipping phenotypes (nondipping, dipping). From 490 consecutive patients with newly diagnosed never-treated

arterial hypertension (mean age 51 ± 11 years, 294 males) subjected to 24-h ABPM, we studied 52 extreme dippers, 52 age- and gender-matched nondippers, and 52 age- and gender-matched

dippers. All patients were subjected to arterial stiffness (PWV), 24-h microalbumin levels, carotid intima-media thickness (cIMT), diastolic dysfunction (E/Ea), and left ventricular mass

index (LVMI) evaluation. ANOVA analysis found no differences regarding HMOD between groups. Multiple regression analysis revealed the following independent direct relationships between: (i)

office SBP and PWV in nondippers (_β_ = 0.35, _p_ = 0.01) and extreme dippers (_β_ = 0.49, _p_ < 0.001), (ii) office SBP and E/Ea in extreme dippers (_β_ = 0.39, _p_ = 0.007), (iii) 24-h

diurnal and nocturnal SBP and E/Ea in dippers (_β_ = 0.40, _p_ = 0.004, _β_ = 0.39, _p_ = 0.005, and _β_ = 0.40, _p_ = 0.004, respectively), and (iv) 24-h and nocturnal SBP and LVMI in

nondippers (_β_ = 0.29, _p_ = 0.04 and _β_ = 0.36, _p_ = 0.009, respectively). In the early phases of untreated-arterial hypertension disease, extreme dipping phenotype in middle-aged

hypertensives does not imply an adverse or favorable prognosis regarding the incidence of HMOD either as continuous variables or as abnormal HMOD compared to other dipping phenotypes. Access

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Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * 2nd Department of Cardiology, Medical School, National and Kapodistrian University of Athens, ATTIKON Hospital,

Athens, Greece Helen Triantafyllidi, Dionyssia Birmpa, Antonios Schoinas, Dimitris Benas, Ioannis Thymis, Mary Varoudi, Dimitris Voutsinos & Ignatios Ikonomidis Authors * Helen

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SUPPLEMENTARY INFORMATION STUDY POPULATION DEMOGRAPHIC AND CLINICAL CHARACTERISTICS 41371_2021_491_MOESM2_ESM.DOC Correlation between systolic blood pressure (24h ABPM and office) and

hypertension mediated organ damage in several dipping phenotypes RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Triantafyllidi, H., Birmpa, D.,

Schoinas, A. _et al._ Is there any true distinction in extreme dipping versus nondipping or dipping phenotype regarding hypertension-mediated organ damage in newly diagnosed and

never-treated hypertensive patients?. _J Hum Hypertens_ 36, 51–60 (2022). https://doi.org/10.1038/s41371-021-00491-x Download citation * Received: 13 August 2020 * Revised: 30 December 2020

* Accepted: 19 January 2021 * Published: 15 February 2021 * Issue Date: January 2022 * DOI: https://doi.org/10.1038/s41371-021-00491-x SHARE THIS ARTICLE Anyone you share the following link

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