The relationship between birth weight (bw), body mass index (bmi) and insulin sensitivity (si) in prepubertal caribbean hispanic (ch) and black african-american (baa) girls with premature adrenarche (pa)


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ABSTRACT 516 _Poster Session II, Sunday, 5/2 (poster 212)_ We have reported that many BAA and CH girls with PA have an increased BMI and a reduced SI that correlate with the degree of


hyperandrogenism ( JCE&M. 80:614, 1995; Peds. Res., 41:73 1997). In addition, children who were born SGA have been reported to have insulin resistance and PA. It has been hypothesized


that the hyperandrogenism and the hyperinsulinism of PA may have common origins in early gestation and are the result of reduced fetal weight. The purpose of this study was to determine the


role of BW and BMI on SI in BAA and CH patients with PA. The BW of 52 (30 CH; 22 BAA) prepubertal fullterm girls with PA were compared to 970 ethnic matched controls (Cazano. C, personal


communication). SI, calculated from the frequently sampled intravenous glucose tolerance test, was available for 25 patients. Patients with reduced SI had an SI more than 2 SD below the mean


for prepubertal girls ( JCE&M 70:1644, 1990). The mean BW and SD score for the entire group and for the children with SI data are listed according to ethnic background. (Table) The BW


of the entire group was significantly lower than normal. There was a significant correlation between SI and BW (r=0.51; p<0.01), and BMI (r=-0.56, p<0.01). Of the eight patients with


reduced SI, 7 were obese and 4 had a reduced BW. Using a multiple linear regression model controlled for BMI, BW still had a significant predictive value for SI (p<0.01). In CH and BAA


patients with PA, both reduced BW and obesity contribute to decreased SI and hyperandrogenism. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Div. Peds Endocrine, Montefiore Medical Center,


A. Einstein Coll. Med, Bronx, NY Gabriella P Grinstein, Patricia Vuguin, Paul Saenger & Joan DiMartino-Nardi Authors * Gabriella P Grinstein View author publications You can also search


for this author inPubMed Google Scholar * Patricia Vuguin View author publications You can also search for this author inPubMed Google Scholar * Paul Saenger View author publications You can


also search for this author inPubMed Google Scholar * Joan DiMartino-Nardi View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS


Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Grinstein, G., Vuguin, P., Saenger, P. _et al._ The Relationship between Birth Weight (BW), Body Mass Index (BMI) and Insulin


Sensitivity (SI) in Prepubertal Caribbean Hispanic (CH) and Black African-American (BAA) Girls with Premature Adrenarche (PA). _Pediatr Res_ 45, 89 (1999).


https://doi.org/10.1203/00006450-199904020-00533 Download citation * Issue Date: 01 April 1999 * DOI: https://doi.org/10.1203/00006450-199904020-00533 SHARE THIS ARTICLE Anyone you share the


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