Increased total and resting energy expenditure in children with cystic fibrosis

ABSTRACT 2078 _Pulmonary: Cystic Fibrosis Poster Symposium, Tuesday, 5/4_ Reduced growth is common in children with cystic fibrosis (CF) and may be caused by increased energy expenditure.

The purpose of this investigation was to examine the components of energy expenditure in a group of school age prepubescent children with CF and age matched, healthy children. Respiratory

calorimetry was used to measure resting energy expenditure(REE); the doubly labeled water method was used to measure total body water (TBW) and total energy expenditure (TEE) over a 1 week

period in all children. The difference between TEE and REE primarily reflects the energy expended in physical activity. Seven patients with CF were studied: age 8.1±1.4 yr, weight 21.6±3.5

kg, length 123.1±5.5 cm (all values mean±SD). All patients had a diagnosis of CF based on results of 2 positive sweat tests. Pulmonary function tests were performed on all patients prior to

study to determine the severity of pulmonary disease. Forced expiratory volumes in 1 second (FEV1) ranged from 44-95% of normal; all patients were receiving pancreatic enzyme supplements at

the time of study. Twelve age matched healthy controls (CTL) were also studied: age 8.1±1.5 yr, weight 27.2±7.3 kg, length 131.0±12.0 cm. CF children plotted significantly below controls in

both weight and length for age: 13 vs. 60 percentile for weight (CF vs. CTL), and 32 vs. 71 percentile for length (CF vs. CTL). Results are summarized below. All values are expressed as mean

± SD, *p≤0.05 vs. CTL. Results were compared using ANOVA. No significant correlations were found between FEV1 and either REE or TEE. (Table) Conclusions: Children with CF tend to be smaller

and leaner than age-matched healthy children. Children with CF have significantly increased REE and TEE compared to healthy children. This increased TEE is due to both increased REE and

increased energy of physical activity. Differences in body composition alone do not appear to completely account for differences in energy expenditure in this population. When normalized to

lean body mass, CF children have 8% higher REE, 13% higher TEE, and 23% higher energy of physical activity than healthy children. Children with CF do not compensate for higher REE by

reducing physical activity. Higher energy expenditure in these children is a contributing factor to the reduced growth seen in these children. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *

Pediatrics, Indiana University Medical Center, Indianapolis, IN Catherine A Leitch, Lynne L Layton, Cheryl A Karn, Robert S Tepper & Scott C Denne Authors * Catherine A Leitch View

author publications You can also search for this author inPubMed Google Scholar * Lynne L Layton View author publications You can also search for this author inPubMed Google Scholar * Cheryl

A Karn View author publications You can also search for this author inPubMed Google Scholar * Robert S Tepper View author publications You can also search for this author inPubMed Google

Scholar * Scott C Denne View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE Leitch, C., Layton, L., Karn, C. _et al._ Increased Total and Resting Energy Expenditure in Children with Cystic Fibrosis. _Pediatr Res_ 45, 352 (1999).

https://doi.org/10.1203/00006450-199904020-02094 Download citation * Issue Date: 01 April 1999 * DOI: https://doi.org/10.1203/00006450-199904020-02094 SHARE THIS ARTICLE Anyone you share the

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