Soluble fas receptor (sfasr) and fas ligand (fasl)in sepsis-induced multiple organ failure ♦ 191


Play all audios:

Fas mediated apoptosis is an important regulatory mechanism in activated immune cells. sFasR can block FasL binding to Fas receptor and inhibit apoptosis in inflammatory cells. We


hypothesized that sFasR, but not FasL, would be increased in persistent multiple organ failure (MOF), where continued inflammation has been reported.1 Plasma from children with sepsis was


assayed for sFasR, FasL, IL-10, IL-6 (ELISA) and nitrite/nitrates (Greiss reaction). Children were separated by a daily organ failure index (OFI)1 into persistent MOF (PMOF=OFI≥3 on day 3);


resolved MOF (RMOF=OFI≥3 day 1 or 2, but < 3 by day 3); and No MOF (OFI<3 days 1-3). sFasR was higher in sepsis vs controls (p<.05). sFasR was higher in PMOF vs RMOF and No MOF


(p=.005) and in nonsurvivors vs survivors(p=.005). FasL was not higher in sepsis vs controls, or PMOF, but was higher in nonsurvivors (p=.01). sFasR, but not FasL, correlated with plasma


IL-10(rs=.4), IL-6(rs=.27), and nitrite/nitrates(rs=.6, all p<.05). In conclusion, sFasR is increased in sepsis, particularly in persistent MOF and nonsurvivors. Increased sFasR, but not


FasL, is associated with inflammation in MOF and may perpetuate inflammation by inhibiting apoptosis of activated immune cells.1 Table REFERENCE * Doughty et al. _Peds Res_ 1996 39: 46A


Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Pediatrics, Wilford Hall Medical Ctr, Lackland AFB, TX, USA Lesley A Doughty, Robert SB Clark & Joseph A Carcillo *


Anesthesiology/CCM, University of Pittsburgh, Pittsburgh, PA, USA Lesley A Doughty, Robert SB Clark & Joseph A Carcillo Authors * Lesley A Doughty View author publications You can also


search for this author inPubMed Google Scholar * Robert SB Clark View author publications You can also search for this author inPubMed Google Scholar * Joseph A Carcillo View author


publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Doughty, L., Clark, R. &


Carcillo, J. Soluble Fas Receptor (sFasR) and Fas Ligand (FasL)in Sepsis-Induced Multiple Organ Failure ♦ 191. _Pediatr Res_ 43 (Suppl 4), 35 (1998).


https://doi.org/10.1203/00006450-199804001-00212 Download citation * Issue Date: 01 April 1998 * DOI: https://doi.org/10.1203/00006450-199804001-00212 SHARE THIS ARTICLE Anyone you share the


following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer


Nature SharedIt content-sharing initiative