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Illness severity scores are essential for NICU outcome comparisons. Current validated scores are CRIB (clinical risk index for babies), SNAP(score for neonatal acute physiology), and SNAP-PE
(SNAP perinatal extension). Unfortunately, CRIB (6 items) is not validated for infants >1,500g BW, while calculation of SNAP (34 items) and SNAP-PE (37 items) are time-consuming. To
overcome these difficulties, we developed and evaluated NAPPI (neonatal acute physiology parameters index)(12 items). Outcomes: data and variables needed to calculate SNAP, SNAP-PE and CRIB
were collected from 10,213 infants in 17 Canadian NICUs in 1996. Subjects were randomly divided into estimation (n=6712) and validation (n=3501) sets, and the method of Pollack et al. was
used to develop NAPPI from admission day SNAP variables. BW and Apgar were added to construct NAPPI-ES (NAPPI extended score) as a SNAP-PE equivalent. The scores were compared with SNAP,
SNAP-PE and CRIB. Model discrimination was evaluated using area under the receiver operating curve (ROC), and calibration by goodness-of-fit tests. Time-to-conduct trials were conducted by a
single individual on 10 sequential NICU admissions at Children's & Women's Health Center of B.C. Results: NAPPI correctly classified patients in groups of increasing probability of death,
irrespective of diagnosis. NAPPI could be calculated in almost half the time required for a SNAP score, is comparable to SNAP and significantly better than CRIB (p< 0.0001) in predicting
mortality for all birth weights. NAPPI-ES is equivalent to SNAP-PE (see table), and is significantly better than NAPPI (p< 0.05, one tailed) in predicting mortality.
(Spon by: Judith Hall) Funded by the MRC, N Y Gen H Fdn, Midland Walwyn Capital Inc, CHEO, Health Care Corp St John's, St Joseph Hlth Ctr, Lawson Research Inst, UWO, Mt Sinai H, HSC, Women's
College Hospital, BCRICWH
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