Treatment outcome of young patients with myelodysplastic syndrome 152


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Between 1985 and 1996, 25 young patients (pts) with myelodysplastic syndrome (MDS) were treated in Fundeni Hospital; mean age 28.5 years (range 16-40 years); sex: 15 female, 10 male. All pts


were classified according to FAB proposals: refractory anemia (RA) 13 (52%) cases, refractory anemia with ring sideroblasts (RAS) 3 cases (12%), refractory anemia with excess of


blasts(RAEB) 4 cases (16%) refractory anemia with excess of blasts in transformation(RAEB-t) 5 cases (20%). The pts were divided into two groups: low-risk pts (RA and RAS, No=16) and


high-risk pts (RAEB, RAEB-t, No=9). Pts of low-risk received transfusions, hormones (cortico-steroids, androgens), while the other group received LDAC. Pts with RAEB may benefit from the


treatment with LDAC, and those who respond to a single course and relapse are more likely to benefit from retreatment. From the low-risk group, 10 pts (62%) are alive and maintain the


remission with supportive treatment; from the high-risk group only 3 (33%) pts are alive. The median survival was 18 mo (range 3 - 67 mo). The two years survival probability for low-risk


group was 46±10% and for high-risk group was 15±10%. Risk factors for the treatment failure were: number of blasts in bone marrow, low colony formation and chromosomal abnormalities. DAC


could be useful for young pts with high-risk MDS when a compatible bone marrow donor is not readily available. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Haematology,


Fundeni Hospital, 258 Soseaua Fundeni, Bucarest, 72437, Romania M Vasilica, D Coriu, M Gociu & D Colita Authors * M Vasilica View author publications You can also search for this author


inPubMed Google Scholar * D Coriu View author publications You can also search for this author inPubMed Google Scholar * M Gociu View author publications You can also search for this author


inPubMed Google Scholar * D Colita View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE


CITE THIS ARTICLE Vasilica, M., Coriu, D., Gociu, M. _et al._ TREATMENT OUTCOME OF YOUNG PATIENTS WITH MYELODYSPLASTIC SYNDROME 152. _Pediatr Res_ 41, 776 (1997).


https://doi.org/10.1203/00006450-199705000-00171 Download citation * Issue Date: 01 May 1997 * DOI: https://doi.org/10.1203/00006450-199705000-00171 SHARE THIS ARTICLE Anyone you share the


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