Changes in myocardial a1 adenosine receptor and message levels during fetal development and postnatal maturation. † 177

Previously we have shown myocardial adenosine A1 receptors are upregulated during the newborn period. The purpose of the present study was to 1) determine the time course of increased A1

adenosine receptors during fetal development and 2) determine if A1 adenosine receptor regulation is secondary to changes in A1 receptor mRNA levels. A1 adenosine receptor density was

determined in whole hearts from fetal rats at 14 and 19 days gestation and from newborn and adult rats using standard receptor binding techniques. A quantitative PCR assay was developed to

measure A1 adenosine receptor mRNA using total heart RNA samples from rats at the above ages. mRNA levels change parallel to receptor number providing evidence for transcriptional control of

receptor density. A1 receptor density and message level increased during late gestation and peaked during the newborn period suggesting a possible role for the myocardial A1 receptor in the

transition to the extrauterine circulation. Figure AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of Pediatrics* and Internal Medicine** University of Virginia, Charlottesville

VA, G. Paul Matherne, Anne M Byford, Joan T Gilrain & Alan C Dalkin Authors * G. Paul Matherne View author publications You can also search for this author inPubMed Google Scholar * Anne

M Byford View author publications You can also search for this author inPubMed Google Scholar * Joan T Gilrain View author publications You can also search for this author inPubMed Google

Scholar * Alan C Dalkin View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE Matherne, G., Byford, A., Gilrain, J. _et al._ Changes in Myocardial A1 Adenosine Receptor and Message Levels During Fetal Development and Postnatal Maturation. † 177. _Pediatr Res_

39 (Suppl 4), 32 (1996). https://doi.org/10.1203/00006450-199604001-00196 Download citation * Issue Date: 01 April 1996 * DOI: https://doi.org/10.1203/00006450-199604001-00196 SHARE THIS

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