TISSUE-SPECIFIC AND DIFFERENTIAL REGULATION OF AT1 AND AT2 GENE EXPRESSION FOLLOWING ADMINISTRATION OF AN AT1 ANTAGONIST DURING FETAL LIFE. † 2186


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Fetal kidney AT2 mRNA levels are elevated early in gestation and decrease with fetal maturation, whereas AT1 mRNA expression increases rapidly before birth. The present study was designed to


determine if the developmental rise in AT1 expression contributes to the decrease in AT2 expression with advancing gestational age. To test this hypothesis, eight pairs of


chronically-instrumented twin fetal sheep (111±2 d gestation, term 145 d) were studied; one of the fetuses received an intravenous infusion of the AT1 antagonist losartan (L) (20μg/kg/min


for 48 h) while the other served as a saline-treated control (C)(0.9% NaCl at 0.1 ml/h). Mean arterial blood pressure did not change in C, but decreased from 40±1 to 33±2 mmHg in L-treated


fetuses(p