Effect of age on furosemide-induced nephrocalcinosis. 2182


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Furosemide (F)-induced nephrocalcinosis (NC) has been traditionally described in LBW prematures. A recent article (J Peds 1994;125:149) reported this complication in older infants with


congestive heart failure. To investigate the role of age on F-induced NC we studied 32 Sprague-Dawley male rats grouped by age and F therapy vs. control for 14 days. The rats were placed in


metabolic cages for measurement of urine output, food and H2O intake. At the end they were anesthetized and exsanguinated. Renal calcium deposition was graded using NC score (scale 0-4) and


by the calcium content(ugm/gm dry tissue) in the contralateral kidney. Table By both indices controls had no NC. All treated groups developed NC with no difference in its magnitude among


themselves. Despite similar initial weights and food intake/100 gm dry wt, treated animals grew less and had higher fluid intake and urine output than their age-matched controls. The more


mature F-treated groups (F and H) had hypokalemia, hypochloremia and increased urinary losses of K and Mg. There were no differences between treated and control groups with regards to Cr


clearance, serum Cr, P and iCa nor in urine Ca, P and Mg excretions/100 gm dry wt. We conclude that the development of NC following two weeks of F treatment is not influenced by age. AUTHOR


INFORMATION AUTHORS AND AFFILIATIONS * Section of Nephrology, The Children's Mercy Hospital, University of Missouri at Kansas City, MO., Alexies V Osorio, Michal M Alon, Michael A


Nichols & Uri S Alon Authors * Alexies V Osorio View author publications You can also search for this author inPubMed Google Scholar * Michal M Alon View author publications You can also


search for this author inPubMed Google Scholar * Michael A Nichols View author publications You can also search for this author inPubMed Google Scholar * Uri S Alon View author publications


You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Osorio, A., Alon, M., Nichols, M. _et al._


EFFECT OF AGE ON FUROSEMIDE-INDUCED NEPHROCALCINOSIS. 2182. _Pediatr Res_ 39 (Suppl 4), 366 (1996). https://doi.org/10.1203/00006450-199604001-02206 Download citation * Issue Date: 01 April


1996 * DOI: https://doi.org/10.1203/00006450-199604001-02206 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a


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