Xanthine oxidase during human fetal development


Play all audios:

ABSTRACT ABSTRACT: Through oxygen free radical production, xanthine oxidase (XOD, E.C.1.2.3.2) has been implicated in the pathogenesis of postischemic and hyperoxic tissue injuries among


newborn. We measured the activity and evaluated the kinetic characteristics of XOD in human fetal liver, intestine, brain, and myocardium. Both the fetal liver and intestine contain a high


XOD activity through gestation. The activity increases in the liver and decreases in the intestine with advancing gestation. The apparent Km for hypoxanthine is 4.8–5.5 μM in the intestine


throughout gestation and in the liver at term but higher than 30 μM in the liver during the first half of pregnancy. The activity is undetectable both in the fetal brain and myocardium


throughout gestation. Thus, XOD activity is present at least in the liver and intestine to account for the oxidation of hypoxanthine and xanthine. However, direct evidence for adenine


nucleotide catabolism, followed by oxidation of the accumulated hypoxanthine during tissue reoxygenation in the human liver or intestine is not available. SIMILAR CONTENT BEING VIEWED BY


OTHERS CHANGES IN ARGINASE ISOFORMS IN A MURINE MODEL OF NEONATAL BRAIN HYPOXIA–ISCHEMIA Article 28 May 2020 IMPACT OF INTRAUTERINE FETAL RESUSCITATION WITH OXYGEN ON OXIDATIVE STRESS IN THE


DEVELOPING RAT BRAIN Article Open access 07 May 2021 DEVELOPMENTAL EXPRESSION OF CATECHOLAMINE SYSTEM IN THE HUMAN PLACENTA AND RAT FETOPLACENTAL UNIT Article Open access 23 March 2024


ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Children's Hospital, University of Helsinki, SF-00290, Finland Kim Vettenranta & Kari O Raivio Authors * Kim Vettenranta


View author publications You can also search for this author inPubMed Google Scholar * Kari O Raivio View author publications You can also search for this author inPubMed Google Scholar


RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Vettenranta, K., Raivio, K. Xanthine Oxidase during Human Fetal Development. _Pediatr Res_ 27, 286–288


(1990). https://doi.org/10.1203/00006450-199003000-00017 Download citation * Received: 30 August 1989 * Accepted: 30 October 1989 * Issue Date: 01 March 1990 * DOI:


https://doi.org/10.1203/00006450-199003000-00017 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is


not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative