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Pituitary function was evaluated in 25 patients with intracraneal Tumors (T). Basal thyroid function (T4, T3 and TSH) was altered in 1/22 patients before (Pre) and in 3/19 within the first
month after surgery (Post). TRH-TSH was abnormal in 7/14 Pre and in 9/18 Post. Basal prolactin (PRL) was high in 4/14 Pre and in 4/15 Post (2 patients had prolactinoma) while TRH-PRL was
high in 3/12 Pre and in 2/15 Post. Serum somatotropin response to a stimuli was < 10ng/ml in 8/14 patients Pre and in 13/15 Post and < 5ng/ml in 5/14 patients Pre and in 7/15 Post. In
pubertal patients gonadotrophic function was deficient in 4/7 Pre and 2/3 Post. In prepubertal patients (n= 8-9), the LH-RH test was normal. Basal cortisol was low in 1/14 Pre and 2/11 Post;
in another 2 patients symptoms of adrenal insufficiency were observed Post. Diabates insipidus was diagnosed in 3/25 patients Pre and in 10/25 Post being transient in 4 of the latter. B-hCG
was high in 2/7 cases, both with germ cell T. A high Pre incidence of somatotrophic, thyrotrophic and pubertal gonadotrophic deficiency was found. PRL was high in prolactinomas and it was
moderately increased in only 2 other patients. Surgical morbidity was low, except for the somatotrophic function.
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