Fetal hind limb oxygen consumption and blood flow during acute graded hypoxia

ABSTRACT ABSTRACT: Hind limb blood flow and O2 uptake, mean blood pressure, and heart rate were measured in six fetal sheep at 127-141 d gestation in the control state and at different

levels of hypoxia that were induced by partial occlusion of the maternal terminal aorta. Blood flow was measured by an ultrasonic flow transducer. Control fetal arterial O2 content ([O2]a)

in the descending aorta was 3.25 + 0.17 mM. In response to graded acute hypoxia, blood flow first increased (22.2 _versus_ 19.9 mL.min−1.100 g−1, _p_ = 0.003) and then decreased abruptly at

approximately 1.5 mM [O2]a.O2 uptake decreased about 12% (14.74 _versus_ 16.71, _p_ = 0.03) as [O2]a decreased to 1.5 mM, and then fell markedly, tending toward zero for [O2]a = 0.9 mM. In

the 2.7- to 1.5-mM [O2]a range, heart rate increased above control (194 _versus_ 169 min−1, _p_ = 0.0024), whereas mean blood pressure did not change significantly. For [O2]a < 1.5 mM,

heart rate decreased to 148 min−1 (_p_ = 0.0005) and mean blood pressure increased above baseline (55 _versus_ 47 torr, _p_ = 0.0001). In conjunction with previous evidence, these results

define a state of acute moderate hypoxia in which the whole fetus can sustain a relatively high rate of oxidative metabolism, and a state of acute severe hypoxia ([O2]a between 1.5 and 1.0

mM) in which O2 uptake by some fetal organs is selectively and markedly decreased. SIMILAR CONTENT BEING VIEWED BY OTHERS RATIO OF VENOUS-TO-ARTERIAL PCO2 TO ARTERIOVENOUS OXYGEN CONTENT

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Open access 23 June 2022 FETOPLACENTAL OXYGEN HOMEOSTASIS IN PREGNANCIES WITH MATERNAL DIABETES MELLITUS AND OBESITY Article 28 July 2022 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND

AFFILIATIONS * Division of Perinatal Medicine, Departments of Pediatrics, Biometrics, and Physiology, University of Colorado School of Medicine, Denver, 80262, Colorado David W Boyle, 

Kathryn Hirst, Gary O Zerbe, Giacomo Meschia & Randall B Wilkening Authors * David W Boyle View author publications You can also search for this author inPubMed Google Scholar * Kathryn

Hirst View author publications You can also search for this author inPubMed Google Scholar * Gary O Zerbe View author publications You can also search for this author inPubMed Google Scholar

* Giacomo Meschia View author publications You can also search for this author inPubMed Google Scholar * Randall B Wilkening View author publications You can also search for this author

inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Boyle, D., Hirst, K., Zerbe, G. _et al._ Fetal Hind Limb Oxygen Consumption and

Blood Flow during Acute Graded Hypoxia. _Pediatr Res_ 28, 94–100 (1990). https://doi.org/10.1203/00006450-199008000-00004 Download citation * Received: 22 January 1990 * Accepted: 11 April

1990 * Issue Date: 01 August 1990 * DOI: https://doi.org/10.1203/00006450-199008000-00004 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

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