Reliability of non-invasive measurement of total body water (tbw)

ABSTRACT Up to now TBW is generally determined on the basis of measurements of D2O concentration in blood after an i.v. dose of D2O. We wondered if TBW could be determined on the basis of

D2O concentrations in urine after giving D2O orally. Eight experiments were carried out in 6 preterm neonates (gest. age: 31.5 wk±3.5, birthweight: 1855 g±516, mean±SD). The D2O

concentrations were measured in every portion of urine voided within 24 h (on the average 16 portions) after giving D2O (2 ml/kg) orally. In 5 experiments D2O concentrations were also

determined in blood. TBW was calculated after extrapolating the regression line after the equilibration period (on the average 5 h) to time 0. After equilibration, the D2O concentration in

urine decreased linearly (r= -0.99±0.01). Using D2O concentration in urine TBW was on the average 1.5% lower than calculated with D2O concentrations in blood. Conclusion: TBW can be measured

on the basis of D2O in urine after giving D2O orally. Considering the high correlation coefficient, we suggest that TBW can be calculated using only 3 portions of urine collected between 6

to 24 h after giving D2O orally. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Dept. of Pediatrics, Div. of Neonatology and Dept. of Physiology, University of Groningen,

Groningen, The Netherlands Peter Hof, Rienk Baarsma, Willem G Zijlstrs, Jaap Zock & Albert Okken Authors * Peter Hof View author publications You can also search for this author inPubMed

 Google Scholar * Rienk Baarsma View author publications You can also search for this author inPubMed Google Scholar * Willem G Zijlstrs View author publications You can also search for this

author inPubMed Google Scholar * Jaap Zock View author publications You can also search for this author inPubMed Google Scholar * Albert Okken View author publications You can also search

for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hof, P., Baarsma, R., Zijlstrs, W. _et al._ RELIABILITY OF

NON-INVASIVE MEASUREMENT OF TOTAL BODY WATER (TBW). _Pediatr Res_ 26, 523 (1989). https://doi.org/10.1203/00006450-198911000-00145 Download citation * Issue Date: 01 November 1989 * DOI:

https://doi.org/10.1203/00006450-198911000-00145 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is

not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative