Oxyhemoglobin affinity modulates cerebral blood flow (cbf) in premature babies


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ABSTRACT Low CBF is thought to cause periventricular leukomalacia in premature babies, but a normal outcome has also been observed. Low CBF found after exchange transfusion in lambs was


explained by the lower oxygen affinity of adult as compared to fetal hemoglobin (HbF). We studied the influence of relative HbF concentration [HbF] and thus the oxygen affinity on CBF in 41


small premature infants: GA 29.1 ±2.0 wks, BW 1064 ±153 g (mean ±ISD). In cerebral ultrasonography 12 were found normal, 14 had subependymal or intraventricular hemorrhage (SEH/IVH), and 15


had intra-parenchymal anomalies (IPE). CBF was measured with the i.v. Xe-133 method at day 1,3 and 7, and [HbF] was obtained chromatographically. In normal babies a positive correlation


between [HbF] and CBF was found: day 1 r= 0.62*, day 3 r=0.64*, day 7 r=0.63* (*=p<0.05). In those with SEH/IVH this correlation was significant only on day 3, in those with IPE only on


day 7. Multiple regression analysis including all babies exept IPE showed a significant influence of [HbF] on CBF, independent of BP, pCO2 and Hct. We conclude that normal babies and to a


lesser extent those with SEH/IVH or IPE can adapt their CBF to the actual oxygen affinity of blood. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Div.of Neonat., Univ.


Children's Hospital, Zürich, Switzerland A Lipp, A Müller, P Tuchschmid & G Duc Authors * A Lipp View author publications You can also search for this author inPubMed Google Scholar


* A Müller View author publications You can also search for this author inPubMed Google Scholar * P Tuchschmid View author publications You can also search for this author inPubMed Google


Scholar * G Duc View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE


Lipp, A., Müller, A., Tuchschmid, P. _et al._ OXYHEMOGLOBIN AFFINITY MODULATES CEREBRAL BLOOD FLOW (CBF) IN PREMATURE BABIES. _Pediatr Res_ 26, 521 (1989).


https://doi.org/10.1203/00006450-198911000-00129 Download citation * Issue Date: 01 November 1989 * DOI: https://doi.org/10.1203/00006450-198911000-00129 SHARE THIS ARTICLE Anyone you share


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