Effect of sympathetic innervation on cerebral blood flow autoregulation in the newborn piglet


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ABSTRACT To evaluate the role of the sympathetic nervous system (SNS) in cerebral blood flow autoregulation (CBF-AR) in the neonatal period, CBF was measured (microspheres) at different


levels of mean arterial blood pressure (MABP) within the normal range for AR (blood withdrawal), following ablation of the right superior sympathetic ganglion in 6 piglets (1.5±0.3 g) and


compared to 6 controls (1.6±0.1 kg). In denervated animals, prior hypotension, CBF is significantly greater than in controls (table); during hypotension, for MABP above 50 mmHg, CBF and MABP


are positively correlated showing a loss of AR [CBF (ml/min/100 g) =5.76 MABP (mmHg)-261, r=0.85, p<.001]. When MABP drop further, CBF remains stable showing the presence of AR as


observed in control animals. These data show a shift of the upper limit of the AR range in denervated animals which suggests a poor adaptation to high MABP. Because of the absence of


differences between the two hemispheres, it is suggested that innervation is blunt only in large vessels supplying the willis circle; an immaturity of the innervation of the distal arteries


could explain this finding. M±SEM, p<0.01 vs controls. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Inserm U272, Faculte de Medecine, Universite de Nancy, 30 rue Lionnois,


France P Monin, F Feillet & P Vert Authors * P Monin View author publications You can also search for this author inPubMed Google Scholar * F Feillet View author publications You can


also search for this author inPubMed Google Scholar * P Vert View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and


permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Monin, P., Feillet, F. & Vert, P. EFFECT OF SYMPATHETIC INNERVATION ON CEREBRAL BLOOD FLOW AUTOREGULATION IN THE NEWBORN PIGLET. _Pediatr


Res_ 26, 520 (1989). https://doi.org/10.1203/00006450-198911000-00128 Download citation * Issue Date: 01 November 1989 * DOI: https://doi.org/10.1203/00006450-198911000-00128 SHARE THIS


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