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We studied the effect of Hypoxanthine (Hx) and Xanthine Oxidase (XOD) on release of [3H]-DA from rat striatal synaptosomes. Synaptosomes were isolated through centrifugation, labelled with
[3H]-DA, recentrifuged and the pellets P2 were used. Hx and XOD, alone or with scavengers, Catalase (CAT) and Superoxide Dismutase (SOD), were added before incubation of the P2. Spontaneous
and K+-evoked (50 mM) release were measured using a filtration method:
These results suggest that oxygen radicals, especially H2O2, may alter neurotransmitter functions. This could represent a neurochemical basis of behavioral changes observed in newborns
during and after a hypoxic episode.
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