Oxygen radicals stimulate dopamine (da) release from rat striatal synaptosomes


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ABSTRACT We studied the effect of Hypoxanthine (Hx) and Xanthine Oxidase (XOD) on release of [3H]-DA from rat striatal synaptosomes. Synaptosomes were isolated through centrifugation,


labelled with [3H]-DA, recentrifuged and the pellets P2 were used. Hx and XOD, alone or with scavengers, Catalase (CAT) and Superoxide Dismutase (SOD), were added before incubation of the


P2. Spontaneous and K+-evoked (50 mM) release were measured using a filtration method: These results suggest that oxygen radicals, especially H2O2, may alter neurotransmitter functions. This


could represent a neurochemical basis of behavioral changes observed in newborns during and after a hypoxic episode. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Inst. Surg.


Res. Rikshosp., OSLO, NORWAY Jan P Poulsen & Ola D Saugstad * Inst. Pat&Clin. Biochem. Charite, BERLIN, GDR Andreas Lun, Christine Scheuch, Hella Gruetzmann & Johann Gross


Authors * Jan P Poulsen View author publications You can also search for this author inPubMed Google Scholar * Andreas Lun View author publications You can also search for this author


inPubMed Google Scholar * Christine Scheuch View author publications You can also search for this author inPubMed Google Scholar * Hella Gruetzmann View author publications You can also


search for this author inPubMed Google Scholar * Ola D Saugstad View author publications You can also search for this author inPubMed Google Scholar * Johann Gross View author publications


You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Poulsen, J., Lun, A., Scheuch, C. _et al._


OXYGEN RADICALS STIMULATE DOPAMINE (DA) RELEASE FROM RAT STRIATAL SYNAPTOSOMES. _Pediatr Res_ 26, 518 (1989). https://doi.org/10.1203/00006450-198911000-00115 Download citation * Issue Date:


01 November 1989 * DOI: https://doi.org/10.1203/00006450-198911000-00115 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link


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