Corticosteroid treatment affects lh bioactivity in pubertal renal transplant patients


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ABSTRACT Delayed onset of pubertal development is common in chronic renal failure (CRF). We investigated nocturnal pulsatile immunoreactive (iLH) and bioactive (bLH) LH secretion between 8


pm and 7 am in 19 pts who had received a renal transplant. Age ranged from 11.7 to 23 yrs; all stages of puberty were represented. Immunosuppression was maintained by corticosteroids and


cyclosporin A and/or azathioprin. The methyl-prednisolone equivalent dosage ranged between 1.2 and 14.7 mg/m2*day. iLH and bLH were determined by RIA and the mouse Leydig cell assay


respectively. Data were analysed by PULSAR and Cluster analysis programmes. LH peak frequency increased with puberty stages to a maximum at PH4. Peak areas were correlated exponentially with


age and TW2 bone age (p=0.02). Peak amplitudes did not change significantly. The mean bLH/iLH ratio was 1.5 ± 0.4. It did not change with age, stage of puberty or serum creatinine. However,


we found a strong inverse relationship with prednisone dosage (r= -0.72, p < 0.002). As LH bioactivity is modulated by enzymatic glycosylation and sialisation, we suggest that


corticosteroid treatment may interfere with these processes. Supported by Deutsche Forschungsgemeinschaft. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * University


Children's Hospital, Heidelberg, F.R.G., Dept. of Biochemistry, Hope Hospital, Salford, U.K. F Schaefer, G Hellstern, R Mitchell, W R Robertson & K Schärer Authors * F Schaefer View


author publications You can also search for this author inPubMed Google Scholar * G Hellstern View author publications You can also search for this author inPubMed Google Scholar * R


Mitchell View author publications You can also search for this author inPubMed Google Scholar * W R Robertson View author publications You can also search for this author inPubMed Google


Scholar * K Schärer View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE


Schaefer, F., Hellstern, G., Mitchell, R. _et al._ CORTICOSTEROID TREATMENT AFFECTS LH BIOACTIVITY IN PUBERTAL RENAL TRANSPLANT PATIENTS. _Pediatr Res_ 26, 513 (1989).


https://doi.org/10.1203/00006450-198911000-00086 Download citation * Issue Date: 01 November 1989 * DOI: https://doi.org/10.1203/00006450-198911000-00086 SHARE THIS ARTICLE Anyone you share


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