Cerebral haemodynamics during failure of oxidative phosphorylation following birth asphyxia


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ABSTRACT Twelve infants born at 36-42 weeks of gestation who had suffered severe birth asphyxia were studied repeatedly in the first week of life by near infrared spectroscopy (NIRS) and


magnetic resonance spectroscopy (MRS). Six infants with normal brains were also studied by NIRS to provide control data. Phosphocreatine/inorganic orthophosphate (PCr/Pi) concentration


ratios determined by MRS following asphyxia were frequently normal in the first 48 hours, but subsequently low ratios were always seen. In the first 48 hours mean cerebral blood volume (CBV)


was elevated (4.40±SEM 0.38ml.100g−1) compared with the control infants (1.98±0.26ml.100g−1, p<0.001), and CBV response to changes in arterial carbon dioxide tension (PaCO2) was reduced


(0.10±0.06 compared with 0.53±0.06ml.100g−1.kPa−1, p<0.001). Cerebral haemodynamics in the asphyxiated infants subsequently returned towards normal. Thus, following birth asphyxia,


elevated blood volume and reduced response to changes in PaCO2 may be detected prior to impairment of oxidative phosphorylation. Supported by the MRC, Wellcome Trust and Hamamatsu Photonics


KK. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Depts. of Paediatrics, and Medical Physics & Bioengineering, University College and Middlesex School of Medicine, London J S


Wyatt, A D Edwards, D Azzopardi, C E Richardson, M Cope, D T Delpy, E B Cady & E O R Reynolds Authors * J S Wyatt View author publications You can also search for this author inPubMed 


Google Scholar * A D Edwards View author publications You can also search for this author inPubMed Google Scholar * D Azzopardi View author publications You can also search for this author


inPubMed Google Scholar * C E Richardson View author publications You can also search for this author inPubMed Google Scholar * M Cope View author publications You can also search for this


author inPubMed Google Scholar * D T Delpy View author publications You can also search for this author inPubMed Google Scholar * E B Cady View author publications You can also search for


this author inPubMed Google Scholar * E O R Reynolds View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions


ABOUT THIS ARTICLE CITE THIS ARTICLE Wyatt, J., Edwards, A., Azzopardi, D. _et al._ CEREBRAL HAEMODYNAMICS DURING FAILURE OF OXIDATIVE PHOSPHORYLATION FOLLOWING BIRTH ASPHYXIA. _Pediatr Res_


26, 511 (1989). https://doi.org/10.1203/00006450-198911000-00069 Download citation * Issue Date: 01 November 1989 * DOI: https://doi.org/10.1203/00006450-198911000-00069 SHARE THIS ARTICLE


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