CEREBRAL HAEMODYNAMICS DURING FAILURE OF OXIDATIVE PHOSPHORYLATION FOLLOWING BIRTH ASPHYXIA


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Twelve infants born at 36-42 weeks of gestation who had suffered severe birth asphyxia were studied repeatedly in the first week of life by near infrared spectroscopy (NIRS) and magnetic


resonance spectroscopy (MRS). Six infants with normal brains were also studied by NIRS to provide control data. Phosphocreatine/inorganic orthophosphate (PCr/Pi) concentration ratios


determined by MRS following asphyxia were frequently normal in the first 48 hours, but subsequently low ratios were always seen. In the first 48 hours mean cerebral blood volume (CBV) was


elevated (4.40±SEM 0.38ml.100g−1) compared with the control infants (1.98±0.26ml.100g−1, p