Atrial natriuretic peptide (anp) concentrations in infants and children receiving intensive care


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ABSTRACT ANP concentrations were measured in 38 children undergoing intensive care. 25 were neonates; 24 with respiratory distress syndrome (RDS) and 5 with patent ductus arteriosus (PDA). 6


infants with arrhythmias and 7 children who underwent the Fontan procedure were also studied. In all groups median ANP concentration was high, although values fluctuated in patients with


RDS or PDA (median 360 pg/ml, range 0 - 2666 pg/ml, normal range 90 - 240 pg/ml). In these 2 groups there was no significant correlation with plasma or urine sodium concentrations, or fluid


intake. There was a significant positive correlation with arginine vasopressin (AVP) concentrations (p<0.001). Treatment of the arrhythmias produced a fall in ANP concentrations (median


before and after: 500 pg/ml and 165 pg/ml, p<0.01). The Fontan procedure produced a significant rise in ANP concentrations (median before and after: 149 pg/ml and 283 pg/ml, p<0.005).


We conclude that sick infants and children often have strikingly elevated ANP concentrations, especially in conditions associated with an increase in right atrial dimensions, but the


diagnostic value of ANP measurement remains to be evaluated. The positive correlation with AVP concentrations was unexpected, and is being further investigated. ARTICLE PDF AUTHOR


INFORMATION AUTHORS AND AFFILIATIONS * Dept. of Child Health, St. George's Hospital, and Bronpton Hospital, London, UK Ri Ross Russell, A Smith, M Burch, S Jeffery, N Carter & P A


Hamilton Authors * Ri Ross Russell View author publications You can also search for this author inPubMed Google Scholar * A Smith View author publications You can also search for this author


inPubMed Google Scholar * M Burch View author publications You can also search for this author inPubMed Google Scholar * S Jeffery View author publications You can also search for this


author inPubMed Google Scholar * N Carter View author publications You can also search for this author inPubMed Google Scholar * P A Hamilton View author publications You can also search for


this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Russell, R., Smith, A., Burch, M. _et al._ Atrial Natriuretic


Peptide (ANP) concentrations in infants and children receiving intensive care. _Pediatr Res_ 26, 509 (1989). https://doi.org/10.1203/00006450-198911000-00059 Download citation * Issue Date:


01 November 1989 * DOI: https://doi.org/10.1203/00006450-198911000-00059 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link


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