Myo-inositol: a newly identified nonnitrogenous osmoregulatory molecule in mammalian brain

ABSTRACT ABSTRACT: Sugar alcohols have been found to play an important osmoregulatory role both in unicellular organisms and, more recently, in multicellular organisms, including mammals.

This study shows that myo-inositol accumulates in the brains of chronically hypernatremic mice, as had been earlier found in rats, and demonstrates for the first time a profound decrease of

myo-inositol in the brains of chronically hyponatremic mice. Together with decreases in better known cerebral osmoles (amino acids and related nitrogenous compounds), the decrease in

myo-inositol apparently allows the brain to balance its intracellular osmolality with that of the plasma, permitting a normal brain water content (no edema) despite profound hyponatremia.

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THEIR REDUCTION BY GLOBAL CEREBRAL ISCHEMIA Article Open access 07 February 2024 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, Washington University

School of Medicine, St. Louis Children's Hospital, St. Louis, 63110, Missouri Jean Holowach Thurston & Richard E Hauhart * Psychiatry, Washington University School of Medicine, St.

Louis Children's Hospital, St. Louis, 63110, Missouri William R Sherman & Robert F Kloepper Authors * Jean Holowach Thurston View author publications You can also search for this

author inPubMed Google Scholar * William R Sherman View author publications You can also search for this author inPubMed Google Scholar * Richard E Hauhart View author publications You can

also search for this author inPubMed Google Scholar * Robert F Kloepper View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints

and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Thurston, J., Sherman, W., Hauhart, R. _et al._ myo-Inositol: A Newly Identified Nonnitrogenous Osmoregulatory Molecule in Mammalian

Brain. _Pediatr Res_ 26, 482–485 (1989). https://doi.org/10.1203/00006450-198911000-00024 Download citation * Received: 19 May 1989 * Accepted: 14 July 1989 * Issue Date: 01 November 1989 *

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