Biliary motility: postnatal changes in guinea pigs


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ABSTRACT ABSTRACT: Intravital microscopy, a new _in vivo_ technique, documented age-dependent changes in choledochoduodenal junction motility in male guinea pigs. In the guinea pig, the


choledochoduodenal junction served as a pump that actively emptied its luminal contents into the duodenum. In the neonates (≤ wk old), this choledochoduodenal junction pump was not fully


developed. Unlike the older guinea pigs, some neonates had an incompetent sphincter ductus choledochi (SDC) allowing retrograde flow of bile during ampullary contractions. While fasting,


neonates had decreased frequency of SDC (1.2 ± 0.4 contractions/min) and ampullary (0.1 ± 0.1 contractions/min) contractions as compared to juveniles (4-6 wk old) (SDC = 6.4 ± 1.0; ampulla =


1.2 ± 0.2 contractions/min) and adults (>1 yr old) (SDC = 6.7 ± 1.6; 0.8 ± 0.2 contractions/min). Following a meal (Ensure), unlike older guinea pigs, the neonate did not have a


significant increased duration and decreased frequency of SDC contractions. Altered neonatal SDC motility correlated with an incompletely developed SDC including decreased muscle mass and


mucosal thickness. By 4 wk of age, choledochoduodenal junction motility was similar to that of the adult. These developmental alterations in junctional motility and structure may affect the


flow of bile into the duodenum contributing to physiologic cholestasis and decreased intraduodenal bile acids seen in neonates. SIMILAR CONTENT BEING VIEWED BY OTHERS VERSATILE APPLICATION


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Article Open access 28 June 2024 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of Pediatrics and Veterinary Medical Anatomy and Primate Center, University of


California, Davis, 95616, California Kenneth L Cox, Anthony T W Cheung, Carleton L Lohse, Erin M Walsh & Christine K Iwahashi-Hosoda Authors * Kenneth L Cox View author publications You


can also search for this author inPubMed Google Scholar * Anthony T W Cheung View author publications You can also search for this author inPubMed Google Scholar * Carleton L Lohse View


author publications You can also search for this author inPubMed Google Scholar * Erin M Walsh View author publications You can also search for this author inPubMed Google Scholar *


Christine K Iwahashi-Hosoda View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS


ARTICLE Cox, K., Cheung, A., Lohse, C. _et al._ Biliary Motility: Postnatal Changes in Guinea Pigs. _Pediatr Res_ 21, 170–175 (1987). https://doi.org/10.1203/00006450-198702000-00012


Download citation * Received: 04 June 1986 * Accepted: 25 September 1986 * Issue Date: 01 February 1987 * DOI: https://doi.org/10.1203/00006450-198702000-00012 SHARE THIS ARTICLE Anyone you


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