Prostaglandin e 2 (pge 2) levels in the lung lavage fluid of premature newborns before and after ductal closure


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ABSTRACT The purpose of our study was to provide evidence for a role of PGE 2 in maintaining ductal patency. As measurements of plasma PGEs in the literature did not correlate well with


ductal patency we examined the tracheal aspirate for PGE 2 by a radioimmunoassay a) in 7 premature newborns (NB) of a mean 28 (26-30) weeks gestation with a mean weight of 880 (710-1180)


grams before and within 24 hours after surgical duct closure performed at a mean age of 12 (7-30) days and b) in 2 NB of 27 weeks and 850 grams with ductal closure by indomethacin. In those


2 duct closure was confirmed by cross sectional and Doppler echo criteria. The PGE 2 levels ranged from 240 - 3770 pg/ml (mean = 1555; median 830) before duct ligation and fell significantly


(p = 0.01) to 0 - 300 (mean 72, median 35) after duct ligation. The wide range of PGE 2 levels before duct closure may be explainedm by the fact, that 2 NB had been treated with bovine


surfactant. The fact, that PGE 2 in the tracheal aspirate disappear or are markedly reduced after surgical or pharmacological duct closure may be due to cessation of local PGE synthesis in


tlw duct tissue itself. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * von Hauner Childrens Hospital, W.-Germany M Vogel, R Roos & K Riegel * Medical Clinic Innenstadt


University of Muenchen, W.-Germany Th Strasser Authors * M Vogel View author publications You can also search for this author inPubMed Google Scholar * Th Strasser View author publications


You can also search for this author inPubMed Google Scholar * R Roos View author publications You can also search for this author inPubMed Google Scholar * K Riegel View author publications


You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Vogel, M., Strasser, T., Roos, R. _et al._


Prostaglandin E 2 (PGE 2) Levels in the Lung Lavage Fluid of Premature Newborns Before and After Ductal Closure. _Pediatr Res_ 22, 217 (1987).


https://doi.org/10.1203/00006450-198708000-00024 Download citation * Issue Date: 01 August 1987 * DOI: https://doi.org/10.1203/00006450-198708000-00024 SHARE THIS ARTICLE Anyone you share


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