Development of colonic transport processes in early childhood: evidence of reduced anion exchange


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ABSTRACT Studies of colonic electrolyte transport in adults and children suggest that anion (movement in vivo is only in part mediated by Cl−/HCO3− exchange mechanism. Using the technique of


non-equilibrium dialysis of the rectum we have investigated anion (exchange by incubating solutions of differing electrolyte composition in children (2 premature infants and 1 neonate, age


33-42 weeks gestation = A, and 3 children aged 5-18 months =B). Using a plasma-like solution, absorption of Cl− and HCO− was greater in A compared with B (see table). As in B HCO3− secretion


might have been expected, we investigated the effect of the electrochemical gradient on HCO3− movement by using a Cl− - free solution to remove anion exchange, and a Na+ -free solution to


remove the etetrical drive for HCO3− absorption. With a Cl− - free solution HCO3− absorption increased in both A and B. With no electrical gradient, Cl− absorption decreased in both groups


but only in B did HCO3− secretion occur. These data support our previous view that anion exchange is poorly developed in infancy, only accounting for 15% of Cl− absorption in infants and


accounting for virtually no Cl− absorption in the preterm neonate. In addition it is clear that, in vivo, Cl− is absorbed by electrical coupling as well as anion exchange. SIMILAR CONTENT


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TRANSPORT IN PARACELLULAR PATHWAYS OF THE CECUM AND LARGE INTESTINE Article Open access 26 April 2023 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Institute of Child Health


& Hospital for Sick Children, London, WC1 H R Jenkins & P J Milla Authors * H R Jenkins View author publications You can also search for this author inPubMed Google Scholar * P J


Milla View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Jenkins, H.,


Milla, P. DEVELOPMENT OF COLONIC TRANSPORT PROCESSES IN EARLY CHILDHOOD: EVIDENCE OF REDUCED ANION EXCHANGE. _Pediatr Res_ 20, 693 (1986). https://doi.org/10.1203/00006450-198607000-00045


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