Gastrointestinal blood flow and o2 uptake in piglets: recovery from hypoxemia


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ABSTRACT ABSTRACT: Gastrointestinal (GI) blood flow, O2 transport, and O2 uptake were measured during recovery from severe hypoxemia in newborn piglets. Hypoxemia was induced by lowering the


inspired O2 concentration to 0.05 for 15 min. This resulted in an 82% decrease in GI O2 uptake. Recovery measurements were obtained 5 and 65 min after restoration of normoxia. During early


recovery (5 min), GI O2 uptake increased above prehypoxemia baseline, presumably to “repay” the O2 deficit incurred during hypoxemia. This was mediated by an increase in the arteriovenous O2


content difference, as GI blood flow did not increase above prehypoxemia baseline. During late recovery (65 min), GI blood flow, O2 delivery, and arteriovenous O2 content difference


decreased below prehypoxemia baseline. This resulted in a 52% decrease in GI O2 uptake below prehypoxemia baseline. Therefore, early recovery was characterized by an appropriate increase in


GI O2 uptake; however, late recovery was characterized by a significant reduction in GI O2 transport and uptake. Circulatory homeostasis was not reestablished during the late recovery


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PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, Section of Neonatology, The Ohio State University and Children's Hospital, Columbus, 43205, Ohio Philip T


Nowicki, Randy R Miller, Nancy B Hansen & John R Hayes Authors * Philip T Nowicki View author publications You can also search for this author inPubMed Google Scholar * Randy R Miller


View author publications You can also search for this author inPubMed Google Scholar * Nancy B Hansen View author publications You can also search for this author inPubMed Google Scholar *


John R Hayes View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE


Nowicki, P., Miller, R., Hansen, N. _et al._ Gastrointestinal Blood Flow and O2 Uptake in Piglets: Recovery from Hypoxemia. _Pediatr Res_ 19, 1197–1200 (1985).


https://doi.org/10.1203/00006450-198511000-00017 Download citation * Received: 11 March 1985 * Accepted: 09 July 1985 * Issue Date: November 1985 * DOI:


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