439 acute and chronic use of the angiotensin i converting enzyme inhibitor (captopril) in childhood hypertension


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ABSTRACT Three patients, aged 10-18 yrs, with uncontrolled hypertension, have been treated with the angiotensin I converting enzyme inhibitor (captopril) for 15-29 mos. Their diagnoses are


malignant hypertension of unknown etiology, Takayasu's arteritis with renal involvement and single kidney hydronephrosis and renal artery stenosis. Two patients had four test doses of


oral captopril in doses of 12.5-50 mg. The changes in Mean Arterial Pressure (MAP) and Plasma Renin Activity (PRA) at 90′ were: Serum aldosterone decreased by 90′ in all tests by an average


of 81.2%, range 78.1-91.2%. The MAP in two patients on captopril alone, 150-250 mg/day, decreased by 6.4 and 18.8%. The third, with Takayasu's arteritis, is taking prazosin in addition


to 400 mg of captopril. His MAP has decreased by 9.6% but he remains severely hypertensive. In all three PRA has remained elevated and serum and urinary aldosterone levels have remained


suppressed. Retinal and cardiac hypertensive changes have improved. We conclude captopril can be a useful therapeutic modality in the treatment of uncontrolled childhood hypertension.


ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * CMDNJ-New Jersey Med. School, Newark and Cornell University Med. College, New York City Robert Rapaport, Lenore S Levine, Harold


Starkman, Sharon E Oberfield, David B Case & Maria I New * Depts. Pediatrics and Medicine, Robert Rapaport, Lenore S Levine, Harold Starkman, Sharon E Oberfield, David B Case & Maria


I New Authors * Robert Rapaport View author publications You can also search for this author inPubMed Google Scholar * Lenore S Levine View author publications You can also search for this


author inPubMed Google Scholar * Harold Starkman View author publications You can also search for this author inPubMed Google Scholar * Sharon E Oberfield View author publications You can


also search for this author inPubMed Google Scholar * David B Case View author publications You can also search for this author inPubMed Google Scholar * Maria I New View author publications


You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Rapaport, R., Levine, L., Starkman, H. _et


al._ 439 ACUTE AND CHRONIC USE OF THE ANGIOTENSIN I CONVERTING ENZYME INHIBITOR (CAPTOPRIL) IN CHILDHOOD HYPERTENSION. _Pediatr Res_ 15 (Suppl 4), 513 (1981).


https://doi.org/10.1203/00006450-198104001-00450 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00450 SHARE THIS ARTICLE Anyone you share the


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