425 effects of testosterone on zinc metabolism in rats


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ABSTRACT We have measured Zinc (Zn) levels in different tissues of castrated rats (CR) fed purified diet containing 100 pp Zn for 6 wks with and without injection of testosterone (T)


enanthate (20 mg IM) 2 wks prior to sacrifice. CR had very low serum T (0.6 ± 0.1 ng/ml) as compared with the controls (8.2 ± 0.7 ng/ml) and T administration restored serum T to normal


levels (9.1 ± 1.1 ng/ml). After castration, serum and tissue Zn levels were significantly decreased with concomitant increase in urinary Zn (see Table). Administration of T to CR increased


the serum and tissue Zn levels almost to the normal level. Since food intake was similar in all groups, T in CR may have increased Zn retention. These results strongly suggest a positive


relationship between Zn and T metabolism. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nassau Cty Med Ctr, SUNY, Stony Brook Health Sciences Ctr, Dept. of Ped., E. Meadow,


11554, NY Mariano Castro-Magana, Sanda Clejan, Shang Y Chen, Vaddanahally T Maddalah & Platon J Colllpp Authors * Mariano Castro-Magana View author publications You can also search for


this author inPubMed Google Scholar * Sanda Clejan View author publications You can also search for this author inPubMed Google Scholar * Shang Y Chen View author publications You can also


search for this author inPubMed Google Scholar * Vaddanahally T Maddalah View author publications You can also search for this author inPubMed Google Scholar * Platon J Colllpp View author


publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Castro-Magana, M., Clejan, S.,


Chen, S. _et al._ 425 EFFECTS OF TESTOSTERONE ON ZINC METABOLISM IN RATS. _Pediatr Res_ 15 (Suppl 4), 511 (1981). https://doi.org/10.1203/00006450-198104001-00436 Download citation * Issue


Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00436 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link


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