380 penetrance of nafcillin into human ventricular fluid: correlation with ventricular pleocytosis and glucose levels


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ABSTRACT Hydrocephalic patients with shunts are prone to infections with Staphylococcus epidermidis and S. aureus. Nafcillin represents an antibiotic of choice for treatment of such


infections because limited data suggest that it penetrates well into the ventricular fluid in the presence of inflammation. Fourteen hydrocephalic children with suspected shunt infections


were studied for penetrance of nafcillin into ventricular fluid following intravenous administration. In seven patients with bacterial ventriculitis, 6.7±2.6% of the peak serum level was


detected in the ventricular fluid. In the remaining seven patients without bacterial ventriculitis, a lower percentage of peak serum levels was detected in the ventricular fluid


(1.32±0.64%). The degree of ventricular pleocytosis was poorly correlated with penetrance of nafcillin (r=0.1343, p=NS). In marked contrast, a strong inverse correlation was present between


ventricular fluid glucose levels and penetrance of nafcillin (r=-0.7275, p<0.001). All patients with normal glucose levels had a very low level of nafcillin. These results suggest that


penetrance of nafcillin into ventricular fluid is linked in an inverse fashion to the mechanism(s) controlling ventricular fluid glucose concentrations. ARTICLE PDF AUTHOR INFORMATION


AUTHORS AND AFFILIATIONS * Northwestern Univ. Medical School, Children's Memorial Hospital, Chicago Ram Yogev, William E Schultz, Sanford B Rosenman & Stanford T Shulman * Wyeth


Laboratories, Radnor, Pennsylvania Ram Yogev, William E Schultz, Sanford B Rosenman & Stanford T Shulman Authors * Ram Yogev View author publications You can also search for this author


inPubMed Google Scholar * William E Schultz View author publications You can also search for this author inPubMed Google Scholar * Sanford B Rosenman View author publications You can also


search for this author inPubMed Google Scholar * Stanford T Shulman View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and


permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Yogev, R., Schultz, W., Rosenman, S. _et al._ 380 PENETRANCE OF NAFCILLIN INTO HUMAN VENTRICULAR FLUID: CORRELATION WITH VENTRICULAR


PLEOCYTOSIS AND GLUCOSE LEVELS. _Pediatr Res_ 15 (Suppl 4), 503 (1981). https://doi.org/10.1203/00006450-198104001-00391 Download citation * Issue Date: 01 April 1981 * DOI:


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