1676 cpap does not alter co2 sensitivity


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ABSTRACT CPAP has been proposed as an effective treatment for the apnea of prematurity. Its mechanism of action is unknown. Twentyfour preterm infants receiving CPAP for the treatment of


respiratory distress were studied at 0,5,and 10cm H2O CPAP. These infants were allowed to breathe 2%,5%,and 8% CO2 for 3 minutes each. During the 3rd minute, recordings of tidal


volume,respiratory rate, and esophageal pressure were made. From these recordings, minute volume,inspiratory time (Ti) ,expiratory time (Te), compliance, duty cycle (Ti/Ttot), tidal


volume/inspiratory time ratio (Vt/Ti) and CO2 sensitivity were calculated. Although CO2 sensitivity rose from 3.9±6.8 cc/min x mm Hg-1 at 0 cm H2O of CPAP to 4.8±8.0 at 10 cm H2O, this


difference was not statistically significant. Significant differences in respiratory rate, Ti, Te, Vt/Ti, and Ti/Ttot were not observed when values for all 3 levels of CPAP were compared.


Measurements of intraesophageal pressure indicated that 62% of the applied airway pressure was transmitted to the mediastinal structures at 5 cm H2O and 54% of applied pressure at 10 cm H2O.


These results suggest that in a group of premature infants with poor CO2 sensitivity that CPAP does not either improve CO2 sensitivity or the drive to breathe, and that other explanations,


such as improvement in arterial blood gases or stabilization of the chest wall must account for the relief of apnea in infants receiving CPAP therapy. ARTICLE PDF AUTHOR INFORMATION AUTHORS


AND AFFILIATIONS * Perinatology Cent., Dept. Pediatrics. Cornell Med. Center, New York, N.Y. A Krauss, R Goldstein, V Alfero, W Frayer & P Auld Authors * A Krauss View author


publications You can also search for this author inPubMed Google Scholar * R Goldstein View author publications You can also search for this author inPubMed Google Scholar * V Alfero View


author publications You can also search for this author inPubMed Google Scholar * W Frayer View author publications You can also search for this author inPubMed Google Scholar * P Auld View


author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Krauss, A., Goldstein,


R., Alfero, V. _et al._ 1676 CPAP DOES NOT ALTER CO2 SENSITIVITY. _Pediatr Res_ 15 (Suppl 4), 723 (1981). https://doi.org/10.1203/00006450-198104001-01695 Download citation * Issue Date: 01


April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-01695 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a


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